geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A new minor histocompatibility locus linked to H-3


, : A new minor histocompatibility locus linked to H-3. Journal of Immunology 126(6): 2378-2381

B10, BALB.B, and A.BY shared an allele at a new locus not shared by B10.LP-H-3b. This locus is linked to the minor histocompatibility gene, H-3, in the 5th linkage group of chromosome 2 of the mouse. The product of the new gene fits the criteria of a minor histocompatibility antigen, since it induced as well as served as a target for cytotoxic lymphocytes (CTL) and its presence accelerated skin graft rejection when compared with that caused by H-3.1. F1 complementation of skin graft rejection and generation of CTL indicated that A.BY and BALB.B do not share H-3a with B10 as previously reported but possess the c allele of their congenic partners A and BALB/c. Thus, B10.LP-H-3b and B10 differ from one another by at least 2 minor histocompatibility loci. The specificity of CTL developed in B10. LP-H-3b and appropriate F1 hybrids indicate that the lytic activity of CTL specific for H-3.1 was restricted to target cells possessing H-2Kb antigens; this contrasted to the H-2Db-restricted activity of CTL specific for the product of the new gene.

US$29.90

PMID: 7229381


Other references

Khalifa, H.F.ad, M.; Awad, Y.; Georgy, M., 1973: Application of Fast Grey RA to the spectrophotometric determination of copper in soft tissues of Egyptain camels. Microchemical journal: 18 (6) 617-621

Avilov, SA.; Kalinovskii, AI., 1989: A new triterpene aglycone from the holothurian Duasmodactyla kurilensis. Khimiya Prirodnykh Soedinenii, 3: 359-361, 445

El'piner, I.E.; Surova, M.D., 1954: Acceleration of processes of decomposition of proteins in the field of ultrasonic waves. Doklady Akademii Nauk SSSR 99(2): 243-246

Grinnell, B.W.; Hermann, R.B.; Yan, S.B., 1994: Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide. The human anticoagulant factor, Protein C, is a plasma glycoprotein that has reported anti-ischaemic and anti-inflammatory properties. To explore potential mechanisms for these reported activities, we examined the effect of Protein C on the proces...

Miller, D.P.; Neuberg, D.; de Vivo, I.; Wain, J.C.; Lynch, T.J.; Su, L.; Christiani, D.C., 2003: Smoking and the risk of lung cancer: susceptibility with GSTP1 polymorphisms. GSTP1 is a gene that helps detoxify foreign substances in the body. Functional polymorphisms of GSTP1 have been studied as risk factors for lung cancer. Past studies have compared the effect of the "at risk" polymorphism in two strata of...

Trifonov, S.; Vasilev, M., 1969: Effect of biomine and NRV preparations on the development and yield of maize. Biomine seed treatment at concentrations of 1-3% or seed soaking in 0.005% NRV (a Soviet naphtha derivative) increased the yield of maize on a dark gray forest soil.

Agústsson, T.; Björnsson, B.T., 2000: Growth hormone inhibits growth hormone secretion from the rainbow trout pituitary in vitro. Growth hormone (GH) secretion in salmonids and other fish is under the control of a number of hypothalamic factors, but negative feed-back regulation by circulating hormones can also be of importance for the regulation of GH secretion. Mammalian s...

Konstadt, S.N.; Reich, D.L.; Rafferty, T., 1996: Validation of a test of competence in transesophageal echocardiography. A test was developed that is based on intraoperative findings to evaluate knowledge of intraoperative echocardiography. This study examines the performance of attending anesthesiologists and residents at various levels of training in order to vali...

Pedersen, T.R., 1995: Secondary prevention of coronary heart disease with lipid lowering drugs. Evaluating outcome eliminates the controversy. Der Internist 36(12): 1174-1178

Lin, T.F.; Tsai, J.C.uan; Yang, J.L.ng, 1998: Influence of planting time and storage on the yield and rice quality of rice cv. Taichung Sen 10. The purpose of this study was to investigate the effect of planting time and storage on rice quality of rice cv. Taichung Sen 10 in Taichung area. It was found that the protein content of grains increased significantly in response to late planting...