+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A new model for inducing total hepatic ischemia while preventing circulatory collapse secondary to splanchnic vascular congestion

, : A new model for inducing total hepatic ischemia while preventing circulatory collapse secondary to splanchnic vascular congestion. Shock 3(6): 440-446

Animal models used to study liver ischemia are limited by the lethal effect of splanchnic venous engorgement from portal triad occlusion (PTO). We compared a passive porto-systemic shunt (PSS) to a pump-driven PSS. The passive and pumped PSS groups (n = 6) received 60 min of PTO followed by 2 h of reperfusion. A control group received all interventions, but no PTO, and remained stable throughout. During PTO, severe circulatory shock with intestinal ischemia occurred in the passive group, while the pumped group remained stable. During reperfusion, both shunted groups experienced varying degrees of metabolic acidosis with decreases in cardiac index, stroke volume, superior mesenteric artery flow, and increases in systemic and intestinal vascular resistance. The mortality rate for the passive group was 83% vs. 0% for the pumped group. These results suggest that pumped PSS prevents splanchnic engorgement and allows for reproducible, isolated total hepatic ischemia in vivo.


PMID: 7656069

Other references

Meyer, I.; Frank, D.; Janssens, U., 2012: A case of venlafaxine-induced syndrome of inappropriate ADH secretion (SIADH) - treatment with tolvaptan. A 74-year-old woman with known COPD was admitted to hospital because of dyspnoa. Clinical and laboratory tests showed an acute pulmonary infection which was treated with antibiotics. Additionally she was found to have a moderately severe episode o...

Jamriska, P., 1991: Influence of different cultivars of spring barley on herbage yield of undersown red clover cultivars. In field trials in 1984-85, the effect of spring barley cv. Orbit and SK-2575 used as companion crops on the establishment and 1st and 2nd year yields of Trifolium pratense cv. Start and Horal (diploid) and Kvarta and Radegast (tetraploid) was inv...

Brown, W.C.; Bishop, S.C., 1948: Eggs of Desmognathusaeneus. Copeia Ann Arbor, 2: 129

Anonymous, 1954: TUMORS of the lip. Medical Times 82(1): 68-72

Lukefahr, M.J.; Martin, D.F., 1965: Additional non-cotton hosts of the boll weevil and cotton leafworm. Four additional species were found to be hosts of the boll weevil, Anthonomus grandis Boheman. These were Cienfuegosia argentina Garcke and C. drummondii (A. Gray) Lewton of South America, C. hildebrandtii Garcke of Africa, and Thespesia lampas Ca...

LaVail, M.M.; Mullen, R.J., 1976: Role of the pigment epithelium in inherited retinal degeneration analyzed with experimental mouse chimeras. In the study of inherited photoreceptor cell degenerations, a difficult problem is to determine the site of the primary genetic defect. It could be either intrinsic to the photoreceptor cells, the pigment epithelial cells or both, or extrinsic to...

Holtzclaw, K.W.; Fraser, M.E.; Gelb, A.; Green, B.D., 1994: Infrared emission from reactions of high-velocity atomic oxygen with black surfaces: Z306 paint, anodized aluminum, and Teflon. Large optical telescopes are being placed into orbit at altitudes where the residual atmosphere can interact with the spacecraft to produce optical emissions, such as the visible shuttle glow. The near-field emissions produced from these interacti...

Porras, D.; Kratz, C.; Loukas, M.; van Doesburg, N.H.; Davignon, A.; Van Praagh, R., 2003: Superoinferior ventricles with superior left ventricle and inferior right ventricle: a newly recognized form of congenital heart disease. We report the first known case of supero-inferior ventricles with a superior morphologically left ventricle and an inferior morphologically right ventricle. This 2 1/2-year-old boy also had dextrocardia, double-outlet right ventricle [S,L,L], righ...

Durand, J.P.; Kollo, B.; Merlin, M.; L.H.sran, J.Y.; Josse, R.; Garrigue, G.P., 1988: Stability of a new thermostable 17D yellow fever vaccine. Journal of Biological Standardization 16(1): 1-7

Limans'kiĭ, I.P.; Zav'ialov, O.V., 1966: Functional relations of the motor and intermediate neurons of the hypoglossal nerve nucleus in the cat. Fiziolohichnyi Zhurnal 12(4): 425-425