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A new model for the study of opiate B-receptors: isolated splenic strip of the cat

, : A new model for the study of opiate B-receptors: isolated splenic strip of the cat. Pharmacology 22(1): 8-14

Noradrenergic neurotransmission in the electrically stimulated isolated splenic strip of the cat was found to be modulated via opiate receptor. Pharmacodynamic parameters of morphine, methionine-enkephalin, azidomorphine, naloxone and N-cyclopropylmethyl-norazidomorphine (CAM) were determined. As CAM proved to be more potent than naloxone in this organ, the cat splenic strip is a useful model for the in vitro testing of opiate B-receptors.


PMID: 6261270

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