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A new model of bone infection used to evaluate the efficacy of antibiotic-impregnated polymethylmethacrylate cement

, : A new model of bone infection used to evaluate the efficacy of antibiotic-impregnated polymethylmethacrylate cement. Clinical Orthopaedics and Related Research: 303-311

An animal model of bone infection was designed for evaluation of the benefits of adding antibiotics to polymethylmethacrylate (PMMA) cement. Femora of New Zealand albino rabbits were exposed at the knee; the medullary canals were entered and the contents aspirated. A known number of bacteria was added to each femur before it was filled with either normal Surgical Simplex P bone cement or Surgical Simplex P antibiotic bone cement. The presence or absence of bone infection was documented by quantitative bacteriologic, roentgenographic, and histologic techniques. Simplex antibiotic bone cement prevented infection, even in the presence of 10(7) bacteria. The effectiveness of the antibiotic bone cement was correlated with the rapid release of high levels of erythromycin (14.1 micrograms/g) and colistin (11.3 micrograms/g) specifically at the site of bacterial contamination.


PMID: 6883865

Other references

Fitzgerald H.E.; Allen T.W., 1977: Effects of circadian rhythms on autonomic functioning and its relationship with performance. Psychophysiology 14(1): 93

Lennox, C.L.; Hoffmann, J.H.; Coutinho, T.A.; Roques, A., 2009: A threat of exacerbating the spread of pitch canker precludes further consideration of a cone weevil, Pissodes validirostris, for biological control of invasive pines in South Africa. Biological control of invasive pine trees in South Africa was first mooted in 1977. Preliminary investigations, starting in 1997, identified two priority target species, Pinus pinaster and P. halepensis, which are not commercially important forest...

Gallo, D.; Jacquemotte, Fçoise.; Cleeren, A.; Laïos, I.; Hadiy, S.; Rowlands, M.G.; Caille, O.; Nonclercq, D.; Laurent, G.; Jacquot, Y.; Leclercq, G., 2007: Calmodulin-independent, agonistic properties of a peptide containing the calmodulin binding site of estrogen receptor alpha. Calmodulin (CaM) contributes to estrogen receptor alpha (ER)-mediated transcription. In order to study the underlying mechanisms, we synthesized a peptide including the CaM binding site: ERalpha17p (P(295)-T(311)). This peptide inhibited ER-CaM as...

Kuma, Y.; Sabio, G.; Bain, J.; Shpiro, N.; Márquez, R.; Cuenda, A., 2005: BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. The compound BIRB796 inhibits the stress-activated protein kinases p38[alpha] and p38[beta] and is undergoing clinical trials for the treatment of inflammatory diseases. Here we report that BIRB796 also inhibits the activity and the activation of...

Anonymous, 1977: Beyond the pay packet. Occupational Health; A Journal for Occupational Health Nurses 29(4): 131-131

Landström, F.; Fredlund, H., 2002: Increasing incidence of Chlamydia infections in Sweden. Shortcomings in primary health care management. The incidence of Chlamydia trachomatis infections in Sweden is increasing. The primary health care encounters many of the patients with C trachomatis infections. The aim of this study was firstly to examine if the primary health care met the requi...

Moore, K.; Brewer, M.A., 2017: Endometrial Cancer: Is This a New Disease?. The incidence of endometrial cancer is increasing, and the age of onset is younger than in prior years. Although endometrial cancer still occurs more commonly in older women, for whom the mortality rate is increasing, it also is being diagnosed in...

Trachtman, H., 2011: Nephrolithiasis--new directions in 2011. Clinical Journal of the American Society of Nephrology 6(8): 2060-2061

Eckhardt, E.R.M.; Renooij, W.;, M.B.M.; Go, P.M.N.Y.H.; Van Erpecum, K.J.; Van Berge Henegouwen, G.P., 1998: Accurate quantification of cholesterol-solubilizing particles in human gallbladder and hepatic biles Potential implications for gallstone formation. Gastroenterology 114(4 PART 2): A520-A521, April 15

Anonymous, 2016: From the diet to the craniotomy. Krankenpflege. Soins Infirmiers 109(4): 10, 56, 80-10, 56, 80