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A new model of glucocorticoid-induced metanephric maldevelopment

, : A new model of glucocorticoid-induced metanephric maldevelopment. Experientia 40(5): 489-490

A new experimental model of glucocorticoid-induced tubular cyst formation has been developed in metanephric organ culture. The addition of cortisol (1.4 X 10(-5) M) to chemically defined serum-free culture medium produces cystic changes during in vitro nephrogenesis . The model isolates the role of glucocorticoids in experimental cyst formation.


PMID: 6723915

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Fomon, S.J.; Ziegler, E.E.; Serfass, R.E.; Nelson, S.E.; Rogers, R.R.; Frantz, J.A., 1999: Less than 80% of absorbed iron is promptly incorporated into erythrocytes of infants. Erythrocyte incorporation of an administered iron isotope has been used as a surrogate for iron retention on the assumption (validated in normal and iron-deficient adults) that 80-100% of the retained isotope is promptly incorporated into circulat...

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