geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A new model of transient hindbrain ischemia in gerbils


, : A new model of transient hindbrain ischemia in gerbils. Journal of Neurosurgery 60(5): 1054-1058

A model of transient hindbrain ischemia in Mongolian gerbils is described. The vertebrobasilar junction of gerbils was exposed by a transcervical approach through the space between the atlas and occipital bone. The origin of the basilar artery was occluded by a clip, and the local cerebral blood flow (CBF) was measured with carbon-14-iodoantipyrine autoradiography. This gerbil model produces ischemia in the thalamus, midbrain, pons, medulla, and cerebellum, where blood flow is supplied from the vertebrobasilar system. Recirculation of blood flow was easily accomplished by removing the clip. Local CBF returned to normal levels immediately after recirculation, then decreased at 30 minutes after recirculation (postischemic hypoperfusion). Almost no effects of local CBF in the forebrain structures were noted during and after hindbrain ischemia. The model may be useful to study the pathophysiological, metabolic, and histopathological effects of ischemia in the vertebrobasilar system.

US$19.90

PMID: 6716140

DOI: 10.3171/jns.1984.60.5.1054


Other references

Waldmann, A., 1999: Monoclonal antibodies to progesterone: characterization and selection for enzyme immunoassay in bovine milk. Thirty-one stabile murine monoclonal antibody (MAb) producing cell lines to progesterone were generated by using a short and a long immunization protocol. Long-term immunization with high doses of 11alpha-hydroxyprogesterone-hemisuccinate-bovine s...

McFarland, J.B.; Gow, J.G., 1967: Trial of gastric cooling for haematemesis. British Medical Journal 3(5569): 831-834

Rosenzweig, E.B., 2010: Tadalafil for the treatment of pulmonary arterial hypertension. Tadalafil, a long-acting phosphodiesterase-5 inhibitor (PDE-5) is the most recent oral agent to receive FDA approval for the treatment of pulmonary arterial hypertension (PAH). With several new agents emerging for the treatment of PAH, this articl...

James, H.L.; Kim, D.J.; Nash, D.R.; Girolami, A., 1994: Recombinant factor X-Friuli biophysical and enzymologic characterization. FASEB Journal 8(7): A1376

McCoy, K.L.; Kendrick, L.; Chused, T.M., 1986: Tolerance defects in New Zealand Black and New Zealand Black X New Zealand White F1 mice. The susceptibility of autoimmune NZB and (NZB X NZW)F1 mice to the induction of tolerance by monomeric BSA was compared with several normal mouse strains. Unresponsiveness in T and B lymphocyte compartments was probed by challenging with DNP8BSA a...

Timmermans C.; Vanhaecke J.; Vrolix M.; Stammen F.; Piessens J.; Geest H.D., 1990: Ridogrel in the prevention of early acute reocclusion after coronary angioplasty. Circulation 82(4 SUPPL 3): III190

Miyata, S.; Miyaji, H.; Kawasaki, H.; Yamamoto, M.; Nishida, E.; Takita, H.; Akasaka, T.; Ushijima, N.; Iwanaga, T.; Sugaya, T., 2017: Antimicrobial photodynamic activity and cytocompatibility of Au 25 (Capt) 18 clusters photoexcited by blue LED light irradiation. Antimicrobial photodynamic therapy (aPDT) has beneficial effects in dental treatment. We applied captopril-protected gold (Au<sub>25</sub>(Capt)<sub>18</sub>) clusters as a novel photosensitizer for aPDT. Photoexcited Au cl...

Van Blerkom L.M., 1989: Viral recombination and epidemics following interspecific and intercultural contact. American Journal of Physical Anthropology 78(2): 317-318

Olofin, I.O.; Spiegelman, D.; Aboud, S.; Duggan, C.; Danaei, G.; Fawzi, W.W., 2015: Supplementation with multivitamins and vitamin A and incidence of malaria among HIV-infected Tanzanian women. HIV and malaria infections occur in the same individuals, particularly in sub-Saharan Africa. We examined whether daily multivitamin supplementation (vitamins B complex, C, and E) or vitamin A supplementation altered malaria incidence in HIV-infec...

Cahn, T.; Houget, J., 1960: On specific dynamic action. Comptes Rendus Hebdomadaires des Seances de L'academie des Sciences 251: 452-454