geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice


, : A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. Journal of Experimental Medicine 159(1): 1-20

A newly discovered autosomal recessive mutation, generalized lymphoproliferative disease (gld), in the C3H/HeJ strain of mice, determines the development of early onset massive lymphoid hyperplasia with autoimmunity. Significant lymph node enlargement is apparent as early as 12 wk of age. By 20 wk, lymph nodes are 50-fold heavier than those of coisogenic C3H/HeJ-+/+ mice. There is a concomitant increase in the numbers of peripheral blood lymphocytes. Analysis of C3H-gld lymph node lymphocyte subsets by immunofluorescence indicates an increase in numbers of B cells, T cells, and null (Thy-1-, sIg-) lymphocytes by 6-, 15-, and 33-fold compared with congeneic control mice. Serologically, gld/gld mice develop antinuclear antibodies (including anti-dsDNA), thymocyte-binding autoantibody, and hypergammaglobulinemia with major increases in several immunoglobulin isotypes. Mutant gld mice live only one-half as long as normal controls (12 and 23 mo, respectively). Interstitial pneumonitis was found in virtually all C3H-gld mice autopsied when moribund. Although immune complexes were detected in the glomerulus by immunofluorescence techniques, only 14% of the autopsied mice had significant lupus-like nephritis. Vascular disease was not found. The pattern of early onset massive lymph node enlargement, hypergammaglobulinemia, and production of antinuclear autoantibodies resembles the basic abnormal phenotype induced by the lpr (lymphoproliferation) mutation. The mutations gld and lpr are not allelic. Linkage studies indicate that gld is located between Pep-3 and Lp on chromosome 1. This new mutation adds another genetically well-defined model to the list of murine lymphoproliferative/autoimmune disorders that may be exploited to gain a clearer understanding of immunoregulatory defects and for identifying common pathogenetic factors involved in systemic autoimmune diseases.

US$29.90

PMID: 6693832


Other references

Shearer P.M.; Oppenheimer D.H., 1981: Evidence for a dipping Moho and a crustal low-velocity zone in The Geysers-Clear Lake region, California. Earthquake Notes 52(1): 49

Freeman, J.; Ferrer, R.L.; Greiner, K.Allen., 2007: Viewpoint: Developing a physician workforce for America's disadvantaged. Eliminating health disparities will be difficult as long as many rural and disadvantaged inner-city communities remain medically underserved. The authors argue that the current debate on physician workforce policy has not adequately emphasized med...

Khanal, D.; Dillon, E.; Hau, H.; Fu, D.; Ramzan, I.; Chrzanowski, W., 2016: Lorentz contact resonance spectroscopy for nanoscale characterisation of structural and mechanical properties of biological, dental and pharmaceutical materials. Scanning probe microscopy has been widely used to obtain topographical information and to quantify nanostructural properties of different materials. Qualitative and quantitative imaging is of particular interest to study material-material interact...

Phillips, J.T.; Leeds, E.B., 1976: A closed technique for canine orchiectomy. The technique is described and illustrated (7 colour figures). In this the common tunic with its epithelial membrane is not opened thus minimizing the tendency for serous fluid to collect.

Bonsignore D., 1986: Functional evaluation of gonalgia using the cybex ii. The Cybex II isokinetic dynamometer was used to assess athletes in whom lesions of the patellar cartilage or femoral condyles had been diagnosed. Examination of the torsion graphs showed the presence of a depression in the torsion curve in extensi...

Chiu, W.T.F.; Chen, Z.S.; Cosico, W.C.; Aglibut, F.B., 2000: Management of slopelands in the Asia-Pacific Region. This book compiles important technical and scientific information from six recent Food and Fertilizer Technology Center seminars on slopeland development. Land and soil characteristics, management and rehabilitation strategies for sloping lands in...

Matias, C., 1994: Effect of sowing date on production and quality of seed of Avena sativa. In field trials in Matanzas, Cuba, A. sativa cv. Cassia Dark, Bentland and an unclassified genotype SC were sown in the 1st fortnight of each month between Sep. and Feb. in rows 50 cm apart. Sowing in Oct. and Nov. respectively gave the highest yi...

D.A.ba, J.; Cardenas, A.; Leza, J.C.; Moro, M.A.; Lizasoain, I.; Lorenzo, P., 1997: Acetylsalicylic acid -induced neuroprotection in an in vitro model of brain ischaemia-reperfusion. Methods & Findings in Experimental & Clinical Pharmacology 19(SUPPL A): 116, Nov

Anonymous, 2015: Employee health. The National Institute for Health and Care Excellence has produced a new guideline looking at improving the health and wellbeing of employees, with a particular focus on organisational culture and context, and the role of line managers.

Moestrup, K.; Ghazanfar, M.N.; Thomsen, S.F., 2017: Patient-reported outcomes (PROs) in chronic urticaria. Chronic urticaria is an itching skin disease which persists for more than 6 weeks. Chronic urticaria has great impact on the daily life of the patient, and the fluctuating nature of the symptoms complicates the monitoring and treatment of the dise...