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A new nitrosourea derivative TA-077, 1-(2-chloroethyl)-3-isobutyl-3-(beta-maltosyl)-1-nitrosourea. I. Comparative study on antitumor activity

, : A new nitrosourea derivative TA-077, 1-(2-chloroethyl)-3-isobutyl-3-(beta-maltosyl)-1-nitrosourea. I. Comparative study on antitumor activity. Cancer ChemoTherapy and Pharmacology 9(3): 134-139

A new water-soluble nitrosourea derivative, 1-(2-chloroethyl)-3-isobutyl-3-(beta-maltosyl)-1-nitrosourea (TA-077), was tested for antitumor activity against murine tumors and a human mammary carcinoma (MX-1) implanted in athymic mice, and the results were compared with those obtained with five other nitrosourea derivatives currently in clinical use: 1-(2-chloroethyl)-3-(methyl-alpha-D-glucopyranos-6-yl)-1-nitrosourea (MCNU), 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea (GANU), 3-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU), chlorozotocin, and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Me-CCNU).


PMID: 6218931

Other references

Cook, J., 1962: The clinical features of Kaposi's sarcoma in the East African Bantu. Acta - Unio Internationalis Contra Cancrum 18: 388-393

Bokeriia, T.F., 1964: Vitamin B12 Content Of The Blood Of Young Children With Pneumonia. Pediatriia 43: 18-23

Rosenfield A.; Buchanan L.; Chapman G.B., 1969: Comparison of the fine structure of spores of 3 species of minchinia haplosporida haplosporidiidae. Journal of Parasitology 55(5): 921-941

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