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A new non-steroidal anti-inflammatory analgesic: gamma-oxo (1,1'-biphenyl)-4-butanoic acid (fenbufen). Chemistry and activity of analogs


, : A new non-steroidal anti-inflammatory analgesic: gamma-oxo (1,1'-biphenyl)-4-butanoic acid (fenbufen). Chemistry and activity of analogs. Arzneimittel-Forschung 30(4a): 695-702

100 analogs of gamma-oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen) were prepared and tested using the carrageenin, polyarthritis, and UV erythema anti-inflammatory tests and the 2-phenyl-1,4-benzoquinone writhing and inflamed paw pressure analgesic tests. Only three retained the same full spectrum of activity as fenbufen: dl-4-(4-biphenyly)-4-hydroxybutyric acid, dl-4-(4-biphenylyl)-1,4-butanediol, and 4-biphenylacetic acid. Fenbufen had the same spectrum of activity as acetylsalicylic acid (ASA), phenylbutazone, and indometacin in the five tests. In addition, dose-response derived potencies show fenbufen more potent than ASA and at least as potent as phenylbutazone in all five tests.

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PMID: 7192122


Other references

Lempereur, L., 1955: Chronic osteomyelitis cured by an atypical resection of the diaphysis followed by central nailing. Acta Chirurgica Belgica 54(9): 947-956

Luna, B.; Doll, S.K.; Hegedus, S.J.; Minshew, N.J.; Sweeney, J.A., 2006: Maturation of executive function in autism. Background Executive c dysfunction has been reported at different ages in autism. It is not clear however. when ibis impairment emerges or bow its expression is affected by development.Methods: 61 non-mentally retarded autism participants (AUT) a...

Bankole, A.; Singh, S.; Hussain, R.; Oestreicher, G., 2009: Condom use for preventing STI/HIV and unintended pregnancy among young men in Sub-Saharan Africa. The condom is the only known method that provides simultaneous protection against unplanned pregnancy and some sexually transmitted infections (STIs), including HIV, among sexually active people. Using data from the Demographic and Health Surveys...

Voskresenskaya, V.V.; Lizgunova, T.V.; Boos, G.V., 1982: Content of isothiocyanates in some species of the genus Brassica L. In a study of varieties of cabbage, cauliflower, broccoli, kohlrabi, Brussels sprouts and kale during 1976-80 in Leningrad province, varietal differences were detected in content of glucosinolates, which ranged in the 22 cabbage varieties studied...

Schindlbeck N.; Klauser A.; Berghammer G.; Voderholzer W.; Mueller Lissner S., 1991: Three year follow up of gastroesophageal reflux disease. Gastroenterology 100(5 PART 2): A156

Usui, H.; Morii, K.; Tanaka, R.; Tamura, T.; Washiyama, K.; Ichikawa, T.; Kumanishi, T., 1997: cDNA cloning and mRNA expression analysis of the human neuronatin. High level expression in human pituitary gland and pituitary adenomas. The authors cloned the nearly complete cDNA of human neuronatin with the aid of an expressed sequence tag (EST) database, and analyzed its expression in various human tissues by Northern blot analysis. The nucleotide and deduced amino acid sequenc...

Pages, J., 1994: Onion varieties in vegetable cropping systems in Senegal. Onions are produced from mid- Dec. to Sep. in the Gandolais region of Senegal, near the mouth of the Senegal River. However, production is irregularly distributed throughout this period. The main constraints to year-round production are outlined a...

Stefanini, M., 2011: Observations on a series of cases of sprue in a prison camp in India. Gastroenterology 8(6): 729-734

Guardabassi, L.; Dalsgaard, A., 2004: Occurrence, structure, and mobility of Tn1546-like elements in environmental isolates of vancomycin-resistant enterococci. The occurrence, structure, and mobility of Tn1546-like elements were studied in environmental vancomycin-resistant enterococci (VRE) isolated from municipal sewage, activated sludge, pharmaceutical waste derived from antibiotic production, seawate...

Terabayashi, S.; Wada, N.; Namiki, T., 1985: Effect of composition of nutrient solution on root hair development in water-cultured tomato. Roots of tomato (cv. Saturn) grown in commercial culture solution had varying amounts of root hairs but no roots were without root hairs. Root hair development was not altered by growth stage. Tomatoes cv. Ohgata-fukujyu were grown in nutrient sol...