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A new oral renal vasodilator, fenoldopam

, : A new oral renal vasodilator, fenoldopam. Clinical Pharmacology and Therapeutics 34(3): 309-315

Fenoldopam, a dopamine agonist, was evaluated in renal clearance studies during water diuresis after oral doses of 25, 50, and 100 mg. After the 100-mg dose there was an increase in urine flow rate, paraaminohippurate clearance, free water clearance, and an increase in the fractional excretion of sodium, calcium, and uric acid. These effects were evident within the first hour, peaked during the second hour, and lasted about 3 hr. Doses of 50 and 25 mg induced smaller increases. There was no significant change in inulin clearance at any dose. To elucidate the mechanism of action, the studies were repeated after treatment with a dopamine-receptor antagonist (metoclopramide). Metoclopramide greatly diminished the renal effects of fenoldopam. These findings indicate that fenoldopam is an active renal vasodilator in man and increases urine volume, free water clearance, and fractional excretion of sodium by stimulation of renal dopamine receptors.


PMID: 6136359

Other references

Kheir-Eldin, A.A.; Motawi, T.K.; Gad, M.Z.; Abd-ElGawad, H.M., 2001: Protective effect of vitamin E, beta-carotene and N-acetylcysteine from the brain oxidative stress induced in rats by lipopolysaccharide. The major goal of this study was to examine the ability of several antioxidants namely, vitamin E, beta-carotene and N-acetylcysteine, to protect the brain from oxidative stress induced by lipopolysaccharide (LPS, endotoxin). LPS, a component of t...

Takizawa T., 1990: Target determination for stereotactic brain operations from three dimensional magnetic resonance imaging data and monitoring with ultrasonographic scans. Stereotactic & Functional Neurosurgery 54-55: 500

Bretz, F.; Dette, H.; Pinheiro, J.C., 2010: Practical considerations for optimal designs in clinical dose finding studies. A key objective in the clinical development of a medicinal drug is the determination of an adequate dose level and, more broadly, the characterization of its dose response relationship. If the dose is set too high, safety and tolerability problems...

Mujic, F.; Lloyd, M.; Cuadrado, M.J.; Khamashta, M.A.; Hughes, G.R., 1995: Prevalence and clinical significance of subungual splinter haemorrhages in patients with the antiphospholipid syndrome. To assess the prevalence and clinical significance of subungual splinter haemorrhages in patients with the antiphospholipid syndrome. A group of 147 patients with the antiphospholipid syndrome (124 female, 23 male) were studied. All patient histor...

Figarella Branger D.; Pellissier J.F.; Serratrice G.; Pouget J.; Bianco N., 1989: Immunocytochemical study of the inflammatory forms of facio scapulo humeral myopathy correlations with other types of myositis. The inflammatory forms of facioscapulohumeral myopathies are rare. In a series of 52 cases, six patients had this types. Only four cases could be investigated with immunochemical stainings (immunoperoxidase). Monoclonal antibodies reactive for B c...

Cha, M-Kyung.; Choi, Y-Soo.; Hong, S-Keun.; Kim, W-Cheol.; No, K.Tai.; Kim, I-Han., 2003: Nuclear thiol peroxidase as a functional alkyl-hydroperoxide reductase necessary for stationary phase growth of Saccharomyces cerevisiae. Yeast nucleus-localized thiol peroxidase (nTPx) was characterized as a functional peroxidase. There are two cysteine residues in nTPx. Replacement of Cys-106 or Cys-111 with serine resulted in a complete loss of thioredoxin-linked peroxidase activ...

Somme, S.; O'Leary, J.P.; Nobel, A., 2001: The Nobel Prize and why there is a prize in physiology or medicine. American Surgeon 67(7): 718-719

Szabo, A.J.; Cole, H.S.; Grimaldi, R.D., 1970: Glucose tolerance in gestational diabetic women during and after treatment with a combination-type oral contraceptive. New England Journal of Medicine 282(12): 646-650

Kim, J.; Roh, Y-Geun.; Cheon, S.; Choe, J-Ho.; Lee, J.; Lee, J.; Jeong, H.; Kim, U.Jeong.; Park, Y.; Song, I.Yong.; Park, Q-Han.; Hwang, S.Woo.; Kim, K.; Lee, C-Won., 2014: Babinet-inverted optical Yagi-Uda antenna for unidirectional radiation to free space. Nanophotonics capable of directing radiation or enhancing quantum-emitter transition rates rely on plasmonic nanoantennas. We present here a novel Babinet-inverted magnetic-dipole-fed multislot optical Yagi-Uda antenna that exhibits highly unidire...

Cockrill, W.R., 1975: Veterinary medicine in China: a blend of art and science. A general discussion on the veterinary education, medicine, surgery and practice in China. The use of acupuncture in animal surgery is also included and a few cases cited.