+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A new oral slow release form of isosorbide dinitrate. Effect on the hemodynamics and exercise capacity of patients with angina

, : A new oral slow release form of isosorbide dinitrate. Effect on the hemodynamics and exercise capacity of patients with angina. Chest 84(6): 707-713

To assess the bioavailability of a new oral and slow release form of isosorbide dinitrate (ISDN-SR), we evaluated 12 patients with confirmed coronary artery disease, chronic stable angina pectoris and abnormal maximal exercise tests (angina-limited and associated with greater than or equal to 0.1 mV ST displacement). Each patient was known to have an increased exercise time after 0.4 mg of sublingual nitroglycerin. Patient responses to exercise on the treadmill at two, four, six, and eight hours after the double-blind administration of 40 mg of ISDN-SR were compared to an identical placebo. It is concluded that 40 mg of this slow release form of isosorbide dinitrate is bioavailable for at least eight hours as demonstrated by significantly improved exercise capacity of the majority (64 percent) of angina patients in this study, each of whom demonstrated anginal limitation to exercise and favorable responses to 0.4 mg of sublingual nitroglycerin.


PMID: 6641305

Other references

Toledo, Rt, 1977: A food engineering option in a food science. Food technology: 31 (10) 55-56

Gomes, S.F.O.; Carvalho, F.A.A.; Fernandes, A.P.S.M.; Tafuri, W.L.; Gazinelli, R.T.; Tavares, C.A.P.; Ferreira, L.A.M., 1998: Treatment of experimental cutaneous leishmaniasis with topical formulations of paromomycin. Memorias do Instituto Oswaldo Cruz 93(SUPPL 2): 314, Nov

Ganzha, E.V.; Starunova, Z.I., 2012: The influence of the degree of infestation with trematode parthenites on the structure of penial glands in the mollusks Littorina saxatilis of different age. Histological and confocal microscopy studies of the structure of penial glands in the Littorina saxatilis males were carried out. The examined mollusks belong to two age groups and were at different stages of spontaneous infection with a trematode...

Freitas, A.P.D.C.E., 1969: Monogenic wheat lines in the differentiation of P. recondita Rob. ex Desm. Using ten international differential hosts supplemented by three further differentials selected in Portugal, nine Portuguese populations of the rust were classified according to race and virulence. Race 20 and subrace 58B are classified as having...

Pernow, J.; Jung, C., 2015: The Emerging Role of Arginase in Endothelial Dysfunction in Diabetes. Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial dysfunction has received increasing attention as a potential co...

Robinson, F.A.; Williams, B.W.; Brown, L.H., 1952: Vhe microbiological assay of vitamin B12 in crude liver extracts. Journal of Pharmacy and Pharmacology 4(1): 27-36

XiaoJiBing; YangJiuTing; XinZongXu, 2008: An experiment study of maize stalk mulching in western area of Liaoning Province. A field trial with a maize variety Nongda 108 was conducted in the western area of Liaoning Province in China in 2004-05 to investigate effects of different maize stalk mulching amounts (0, 3000, 7500 and 12 000 kg/ha) on soil property and maize y...

Tartaro, S.; Stroffolini, F.; Lepore, M., 1979: The importance of etiology for the successful treatment of secondary trigeminal neuralgia. Reviews of some clinical cases. Incorrect etiopathological evaluation of trigeminal neuralgia could result in therapeutic mistakes. Some of the clinical cases encountered are reviewed to point out diagnosis leading to valid therapeutic approaches.

Yakushijin, Y.; Grogan, T.; Shipp, M., 1996: Antigen processing pathways in aggressive non-Hodgkins lymphomas Enhanced expression of LMP-2, LMP-7 and TAP-1 in high risk patients. Blood 88(10 SUPPL 1 PART 1-2): 377A

Saunders, R.S., 1976: The cost of contraceptive supplies. Finance & Development 13(4): 43-44