+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A new orally active male antifertility agent

, : A new orally active male antifertility agent. Contraception 9(5): 459-470

CL 88,236 (1-1-amino-3-chloro-2-propanol HC1) was tested orally for antifertility in male rats, mice and hamsters. It was given orally in propylene glycol either daily for 14 days with mating on Days 7-14, (or for 7 days with mating on Days 2, 4, and 6, or for 7 days every other week for 3 weeks in withdrawal tests. In male rats, 5 mg per kg for 14 days reduced number of pregnant females 50%, and at 10-80 mg per kg males were completely sterile. Libido, coitus, and ejaculation were normal, but fragmented sperm, spermatogenic arrest, and granuloma-like epididymal lesions appeared at 40 and 80 mg per kg. Serial matings showed that sterility developed within 6 days and lasted for 1 week after withdrawal. Sterility was maintained by treating rats with CL 88,236 on alternating weeks. Male mice and hamsters were sterilized by 300 mg per kg per day for 14 days, without toxicity. Sterility was apparently mediated by affecting epididymal and vas sperm stores.


PMID: 4448078

Other references

Holman, GM.; Cook, BJ., 1979: The analytical determination of proctolin by HPLC and its pharmacological action in the stable fly. A method utilizing high performance liquid chromatography as a purification technique and for quantitative analysis of proctolin (Arg-Tyr-Leu-Pro-Thr) in whole-body extracts of the stable fly, Stomoxys calcitrans (L.) was developed. Analysis of ne...

Hill, E.M.; Wickler, S.J.; Szewczak, J.M.; Greene, H.M.; Cogger, E.A., 2001: 2,3-Diphosphoglycerate in burros after six weeks at altitude. Research from our laboratory indicates that both horses and mules increase concentrations of 2,3-DPG in their red cells after acclimatization to high altitude. This increase has been argued to aid in the acclimatization process by facilitating oxy...

Cohen-Mansfield, J.; Libin, A.; Marx, M.S., 2007: Nonpharmacological treatment of agitation: a controlled trial of systematic individualized intervention. The objective of this study was to examine the efficacy of a systematic algorithm for providing individualized, nonpharmacological interventions for reducing agitated behaviors in nursing home residents with dementia. This placebo-controlled study...

Darling, H.C.Rutherford, 1929: Elementary hygiene for nurses. Elementary hygiene for nurses 4th ed 292 p

Sung, B.; Kim, M.Su.; Corrigan, A.; Donald, A.M.; Soh, K-Sup., 2009: In situ microextraction method to determine the viscosity of biofluid in threadlike structures on the surfaces of mammalian organs. We report a method to measure the viscosity of microL volumes of biofluid obtained from threadlike structures (NTSs) on the surfaces of mammalian (rabbit) internal organs. The fluid was mechanically microextracted in situ from NTSs on the organ su...

Anderson N.S.; Pine S.M.; Rosenfeld A., 1975: Derived scales for degree of simultaneous contrast in 6 benussi ring figures. Bulletin of the Psychonomic Society 6(3): 289-292

Stratton, R., 1971: The firemouth cichlid. Aquarium NJ: 48: 8-11

Lynch H.D.vid; Morgan Paul, 1981: Finite element models of passive continenal rifts. Eos, Transactions, American Geophysical Union 62(45): 1031-1032

Stine, R.; Robinson, J.T.; Sheehan, P.E.; Tamanaha, C.R., 2011: Real-time DNA detection using reduced graphene oxide field effect transistors. Advanced Materials 22(46): 5297-5300

Teboul, J.L.; Zapol, W.M.; Brun-Buisson, C.; Abrouk, F.; Rauss, A.; Lemaire, F., 1989: A comparison of pulmonary artery occlusion pressure and left ventricular end-diastolic pressure during mechanical ventilation with PEEP in patients with severe ARDS. When positive end-expiratory pressure (PEEP) is applied to normal lungs, the pulmonary artery occlusion pressure (PAOP) may reflect alveolar pressure and not left ventricular end-diastolic pressure (LVEDP). The reliability of PAOP measurements has...