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A serial study of peripheral blood T lymphocyte subsets in relapsing-remitting multiple sclerosis


, : A serial study of peripheral blood T lymphocyte subsets in relapsing-remitting multiple sclerosis. Annals of Neurology 15(3): 250-256

Twelve patients with relapsing-remitting multiple sclerosis and 3 control subjects were evaluated weekly for six months. Peripheral blood lymphocyte subsets were enumerated using monoclonal antibodies and analysis with a dual-laser fluorescence-activated cell sorter. Results were correlated with clinically assessed disease activity. Fluctuations occurred in the number of T lymphocytes (Leu 1+) and cells with the helper/inducer phenotype (Leu 3a/OKT4+) in both patients and controls. Fluctuations in the number of cells with the suppressor/cytotoxic (Ts/c) cell phenotype (OKT5, OKT8, Leu 2a+) also occurred. Variations in the relative numbers of cells labeled with all three Ts/c monoclonals did occur, but with OKT5 generally labeling fewer cells than OKT8 or anti-Leu 2a. When findings were correlated with disease activity, OKT5 was a more sensitive gauge of disease activity than either OKT8 or anti-Leu 2a. When peripheral blood lymphocyte subsets were correlated with disease activity, the following patterns were observed: a reduction in the number of Ts/c cells without evidence of clinical disease (four episodes), the development of new symptoms suggestive of an acute relapse but without a reduction in the number of Ts/c cells (two episodes), and a reduction in the number of Ts/c cells associated with acute relapse (two episodes). In the two patients with acute relapse and a reduction in the number of Ts/c cells, clinical disease preceded a reduction in the number of Ts/c cells in 1 patient, whereas the two events occurred simultaneously in the other patient. Taken together, these limited results indicate that in some cases a reduction in the number of Ts/c cells may be the result rather than the cause of disease activity and may represent an epiphenomenon.

US$19.90

PMID: 6232891

DOI: 10.1002/ana.410150308


Other references

Tayyar, R.I.; Waines, J.G., 1996: Genetic relationships among annual species of Cicer(Fabaceae) using isozyme variation. In order to determine the pattern of genetic diversity within and among the species of Cicer and to estimate interspecific genetic relationships, allelic variation was assayed for 23 isozyme loci in 63 accessions of 11 species of Cicer using starc...

Murai, H.; Suzuki, Y.; Kiyosawa, M.; Tokumaru, A.M.; Ishiwata, K.; Ishii, K., 2016: Cerebral glucose metabolism in the striate cortex positively correlates with fractional anisotropy values of the optic radiation in patients with glaucoma. It has recently become clear that glaucoma is not only an ocular disease, but involves central visual pathways as well. The purpose of this study was to examine functional and structural alterations in the brains of glaucoma patients. Case-control...

Babcock, G.T.; Vickery, L.E.; Palmer, G., 1976: Electronic state of heme in cytochrome oxidase. I. Magnetic circular dichroism of the isolated enzyme and its derivatives. Magnetic circular dichroism (MCD) spectra have been recorded for beef heart cytochrome oxidase and a number of its inhibitor complexes. The resting enzyme exhibits a derivate shape Faraday C term in the Soret region, characteristic of low spin fer...

Maheswaran M.; Rangasamy S.R.S., 1992: Changes in peroxidase activity during shoot formation in oryza sativa l. Callus cultures were established from mature seeds of rice variety IR 50 on MS basal medium supplemented with varying combinations of 2,4-D and kinetin. The presence of 2,4-D 2 mg/l and kinetin 0.5 mg/l in the induction medium was found to be effe...

Zheng-Shui-Er; Jin-Jie; Tong-Xiang-Min; Qian-Wen-Bin; Xue-Yong-Quan, 2006: Effects of ST1571 on the development of dendritic cells derived from bone marrow mononuclear cells in patients with chronic myeloid leukemia. Objective To investigate the effects of ST1571 on the development of dendritic cells DC) derived from bone marrow mononuclear cells of patients with chronic myeloid leukemia( CML). Methods Bone marrow mononuclear cells ( BMMNC) from CML patients...

Solimena, M.; Dirkx, R.; Hermel, J.M.; Pleasic-Williams, S.; Shapiro, J.A.; Caron, L.; Rabin, D.U., 1996: ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. Islet cell autoantigen (ICA) 512 is a novel autoantigen of insulin-dependent diabetes mellitus (IDDM) which is homologous to receptor-type protein tyrosine phosphatases (++PTPases). We show that ICA 512 is an intrinsic membrane protein of secretor...

Falk, R.H.; Lee, V.W.; Rubinow, A.; Hood, W.B.; Cohen, A.S., 1983: Sensitivity of technetium-99m-pyrophosphate scintigraphy in diagnosing cardiac amyloidosis. To determine the value of technetium-99m-pyrophosphate myocardial scintigraphy in the diagnosis of amyloid heart disease this procedure was prospectively performed in 20 consecutive patients with biopsy-proven primary amyloidosis. Eleven patients...

Su, K-Cheng.; Tsai, C-Chien.; Chou, K-Ta.; Lu, C-Chen.; Liu, Y-Yang.; Chen, C-Sheng.; Wu, Y-Chung.; Lee, Y-Chin.; Perng, D-Warng., 2012: Spontaneous breathing trial needs to be prolonged in critically ill and older patients requiring mechanical ventilation. To investigate a modified weaning procedure to predict extubation outcome in critically older and ventilated patients. We retrospectively analyzed extubation outcome in older (≥ 70 years) and ventilated patients. In period I (2007), patients pas...

Ando, H.; Natsume, A.; Senga, T.; Watanabe, R.; Ito, I.; Ohno, M.; Iwami, K.; Ohka, F.; Motomura, K.; Kinjo, S.; Ito, M.; Saito, K.; Morgan, R.; Wakabayashi, T., 2014: Peptide-based inhibition of the HOXA9/PBX interaction retards the growth of human meningioma. Meningiomas are the most common type of intracranial tumor, accounting for between 24 and 30 % of primary intracranial tumors. Thus far, no biomarkers exist to reliably predict the clinical outcome of meningiomas. A previous genome-wide methylatio...

Trezise, A.E.; Buchwald, M.; Higgins, C.F., 1993: Testis-specific, alternative splicing of rodent CFTR mRNA. Human Molecular Genetics 2(6): 801-802