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A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus


, : A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus. Arthritis and Rheumatism 25(1): 48-54

A serial study of reticuloendothelial system splenic Fc receptor function was undertaken in 13 patients with systemic lupus erythematosus (SLE). Fc receptor function was assessed by measuring the clearance half times of IgG-sensitized 51Cr-labeled autologous erythrocytes from the circulation. Prolonged clearance half times were initially detected in all patients, and the magnitude of the clearance defect was significantly correlated with disease activity (P less than 0.01, Spearman rank correlation) and immune complex levels (P less than 0.01). Clinical course and changes in receptor functional activity over time were found to be significantly correlated. Clearance half-times tended to return to normal in all 11 patients who clinically improved. The clearance half-time remained unchanged in 1 patient whose disease activity was stable, and it worsened in 1 patient whose illness flared. Levels of immune complexes also changed concordantly with clearance half-times and disease activity. These studies underscore the interrelationship between the presence of circulating immune complexes, defects in Fc receptor function that might lead to prolonged circulation of these complexes, and disease activity in SLE.

US$29.90

PMID: 6978134


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Vaudano, A.Elisabetta.; D.B.naventura, C.; Carni, M.; Rodionov, R.; Lapenta, L.; Casciato, S.; Fattouch, J.; Egeo, G.; Pantano, P.; Nucciarelli, V.; Maraviglia, B.; Prencipe, M.; Lemieux, L.; Giallonardo, A.Teresa., 2012: Ictal haemodynamic changes in a patient affected by "subtle" Epilepsia Partialis Continua. We report on a 64 year-old woman presenting with Epilepsia Partialis Continua (EPC) affecting the left hand since the age of 24 without neurological deficit. Structural MRI showed a region of focal cortical dysplasia (FCD) over the right central g...

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Priboth, W.; Wujanz, G., 1969: Comparative radiologico-photometric and biopsy-chemical examinations for the early diagnosis of rickets in cattle. Archiv für Experimentelle Veterinarmedizin 23(2): 233-237

Gobbi, M.; Mennini, T., 1999: Release studies with rat brain cortical synaptosomes indicate that tramadol is a 5-hydroxytryptamine uptake blocker and not a 5-hydroxytryptamine releaser. Tramadol is a centrally acting opioid analgesic whose mechanism of action could also involve an increase in central serotoninergic transmission. Thus, tramadol inhibits synaptosomal serotonin (5-hydroxytryptamine, 5-HT) reuptake and induces tritiu...

Batista, A.C.; D.L.ma, J.A.; Pessoa, F.P.; Shome, S.K., 1963: E. brasiliensis sp.nov., a Hyphomycete of interest for human mycopathology. This fungus was first isolated from the sputum of a man from whose lung a chronic abscess (not tubercular) had been surgically removed in Dec. 1957 and who nevertheless continued to cough, produce grey sputum, and run a temperature. Its mycologica...

Reynolds, D.M.; Ahmad, S.R., 1997: Rapid and direct determination of wastewater BOD values using a fluorescence technique. The biodegradable constituents in wastewater are parameterized by the biochemical oxygen demand (BOD) values. The technology based on fluorescence detection for the real-time, non-invasive monitoring of the biodegradable constituents of various se...

Wang, Jia Fu, 1993: Two new species of segestriid spiders from China (Araneae: Segestriidae). Acta Zootaxonomica Sinica ; 18(4): 417-420

Wheeler, R.M.; Wheeler, R.M., 2003: Carbon balance in bioregenerative life support systems: some effects of system closure, waste management, and crop harvest index. In Advanced Life Support (ALS) systems with bioregenerative components, plant photosynthesis would be used to produce O2 and food, while removing CO2. Much of the plant biomass would be inedible and hence must be considered in waste management. Th...

Pavlov N.A., 1987: The system prostacyclin thromboxane a 2 in coronary heart disease. Sovetskaya Meditsina (2): 36-39

Patel, V.B.; Griffin, B.P., 1999: Anomalous coronary artery, aortic dissection, and acute myocardial infarction. The combination of acute coronary occlusion and aortic dissection because of involvement of one or other coronary vessels in the dissection flap is uncommon. Furthermore, the occurrence of an anomalous coronary artery and its involvement in acute...