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A series of inhibitors of azo dye hepatocarcinogenesis partially reverse the azo dye-induced decrease in liver RNA/DNA ratio


, : A series of inhibitors of azo dye hepatocarcinogenesis partially reverse the azo dye-induced decrease in liver RNA/DNA ratio. Research Communications in Chemical Pathology and Pharmacology 38(2): 255-269

The DNA and RNA content and the mitotic index were determined in the livers of rats pair-fed for 10 days on a control diet, and diets containing 0.06% 3'-methyl-4-dimethylaminoazobenzene (3'MeDAB), either alone or in combination with the inhibitors of azo dye carcinogenesis acetanilide (0.08%), p-hydroxypropiophenone (PHP, 1%), urea (5%), dehydroacetic acid (DHAA, 0.25%), butylated hydroxytoluene (BHT, 0.3%) and 3-methylcholanthrene (3MC, 0.067%). The liver RNA/DNA ratio was increased in rats fed the 3'MeDAB diet following ingestion of each of the inhibitor plus carcinogen-containing diets. The increases were significant except in the instance of urea. The increase was mainly due to increased RNA content in rats fed 3'MeDAB plus acetanilide, DHAA, BHT and 3MC when compared with rats fed 3'MeDAB alone. In rats fed PHP and 3'MeDAB, an increase in total liver DNA that was noted in rats fed 3'MeDAB alone did not take place, while total liver RNA content was similar in both groups; the RNA/DNA ratio was therefore greater in rats protected from 3'MeDAB carcinogenesis by PHP. The results are discussed in relationship to the effects of carcinogens on RNA forming genes and the role of the nucleolus in cell differentiation.

US$29.90

PMID: 6187053


Other references

Folgarait P.J.; Davidson D.W.; Adondakis S., 1990: Biotic and chemical defenses in myrmecophytic cecropia. Bulletin of the Ecological Society of America 71(2 SUPPL): 154

Fogg, J.M.; Schofield, M.J.; Declais, A.C.cile, 2000: Yeast resolving enzyme CCE1 makes sequential cleavages in DNA junctions within the lifetime of the complex. CCE1 is a DNA junction-resolving enzyme of Saccharomyces cerevisiae. Such enzymes are required to make two symmetrically paired cleavages in order to resolve the four-way junction productively. Using a cruciform assay, we show here that CCE1 intro...

Hackley Keith C.; Liu Chao Li; Wang Hong, 1997: Methane leakage from underground storage field; source identification, geologic implications, and effects on soil and crops. Gas was detected bubbling up in stream beds and in soil probes on farmland overlying a large underground gas storage facility in Illinois. The gas storage facility was developed in an asymmetrical anticline in sandstone approximately 2200 feet bel...

Minervini J.; O.C.nnor J.E.; Wells R.E., 2003: Inundation map, ice-rafted erratics, and deposits of late Pleistocene Missoula floods in the Portland Basin and Willamette Valley, Oregon and Washington. Glacial Lake Missoula, impounded by the Purcell Trench lobe of the late Pleistocene Cordilleran Icesheet, repeatedly breached its ice dam, sending floods as large as 2,500 cubic kilometers racing across the Channeled Scabland and down the Columbia...

Webb, N.R. ., 1969: Temperature and respiratory metabolism in a species of soil mite. Unknown

O.Neal Michael A., 2004: Moraine degradation processes as a primary control on the size-frequency distribution of a lichen population. This study investigates moraine degradation as a primary control on lichenometric dating techniques, with the aim of providing the lichenometrist with a better idea of which portion of a lichen population is likely to provide the most accurate lan...

Hausman, G.J.; Hausman, D.B., 1993: Endocrine regulation of porcine adipose tissue development: cellular and metabolic aspects. The review concludes that somatotropin, thyroxine and glucocorticoids have important roles in adipose tissue development, and that insulin-like growth factor-1 and transforming growth factor- beta may be important in the differentiation of adipose...

Baker, C.H.; Wilmoth, F.R.; Sutton, E.T.; Takach, K., 1982: Red blood cell and plasma distribution in SHR cremaster muscle microvessels. Distribution of blood in the cremaster muscle microvasculature of spontaneously hypertensive (SHR) and Wistar-Kyoto normotensive (WKY) rats was determined by fluorescence videomicroscopy and densitometry. Bolus intra-arterial injections of fluores...

Ivano V.A.I., 1971: Developing desert lands N. of the Aral Sea. Agriculture and grazing land development in a desert area N. of the Aral Sea in the Kazakh SSR are discussed following an outline of natural conditions of the area, where annual precipitation is 58-220 mm and open-surface evaporation 1400-1600 mm....

Skarmeta J.; Charrier R., 1976: Geology of the continental region of Aisen between 45 degrees and 46 degrees South latitude, Chile. Actas del Congreso Geologico Argentino 6, Vol