geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A serine-proteinase inhibitor (Boc-D-Phe-Pro-Arg-H) inhibits the secretion of adrenocorticotropin- and beta-endorphin-immunoreactive peptides in vitro


, : A serine-proteinase inhibitor (Boc-D-Phe-Pro-Arg-H) inhibits the secretion of adrenocorticotropin- and beta-endorphin-immunoreactive peptides in vitro. Neuropeptides 3(1): 65-70

The effects of a potent serine protease inhibitor, Boc-D-Phe-Pro-Arg-H, on the secretion and content of ACTH and beta-endorphin-like immunoreactivities of cultured rat anterior pituitary cells were studied. Basal release of the hormones was not affected by the drug but secretion in response to stalk-median eminence extracts was inhibited. The inhibitor did not effect the amount of ACTH or beta-endorphin in the medium plus the cells, nor did it change the ratio of the lipotropin and beta-endorphin-like immunoreactivities. Thus the compound seems to affect the release of ACTH and beta-endorphin, but not the processing of lipotropin to beta-endorphin.

US$29.90

PMID: 6296720


Other references

Petrides, A.S.; Vogt, C.; Schulze Berge, D.; Matthews, D.; Strohmeyer, G., 1994: Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis. Glucose intolerance and diabetes mellitus are both prevalent in cirrhosis, yet the pathogenesis of impaired glucose metabolism remains unknown. Therefore insulin secretion (hyperglycemic clamp, + 125 mg/dl), insulin sensitivity (euglycemic hyperin...

Yu, Z-Yan.; Chen, L-Sheng.; Zhang, L-Chang.; Zhou, T-Biao., 2012: Meta-analysis of the relationship between ACE I/D gene polymorphism and end-stage renal disease in patients with diabetic nephropathy.   Diabetic nephropathy (DN) is the major cause for end-stage renal disease (ESRD) and the pathogenesis for DN developing into ESRD is not clear at present. Results from published studies on the relationship between angiotensin-converting enzyme...

Melloh, M.; Barz, T., 2011: Structural LSI can occur in the absence of functional LSI. Journal of Orthopaedic and Sports Physical Therapy 41(7): 534; Author Reply 535-534; Author Reply 535

Sztuder, H.; Swierczewska, M., 2000: Efficiency evaluation of the nitrogen, magnesium and micronutrients foliar application to winter triticale and spring barley. A series of field experiments in Poland (1995-98) were conducted to assess foliar nutrition of winter triticale and spring barley with nitrogen, magnesium and micronutrients. Both main crop and by-product mass as well as nitrogen and magnesium upt...

Franzetti, M.; Lai, A.; Simonetti, F.Roberto.; Bozzi, G.; D.L.ca, A.; Micheli, V.; Meraviglia, P.; Corsi, P.; Bagnarelli, P.; Almi, P.; Zoncada, A.; Balotta, C., 2012: High burden of transmitted HIV-1 drug resistance in Italian patients carrying F1 subtype. Transmitted drug resistance (TDR) is mainly restricted to individuals carrying B subtype, with low prevalence among non-B subtypes when grouped together. Subtype F1 is the most frequent non-B variant found in subjects living in Italy, allowing a s...

Guo, L-Na.; Pei, Y-Hu.; Xie, F-Xiang.; Liu, L.; Cong, H.; Cui, H-Xia.; Wang, X-Li.; Li, W-Jing.; Jian, B-Yu.; Liu, J-Cheng., 2016: Identification of antioxidant activity of two new aromatic ring butyrolactone derivatives from Dictamnus dasycarpus Turcz. NlmCategory="UNASSIGNED">The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, da...

Altendorf; Chen; Irwin; Liang; Hardy, 1993: Temperature dependences of the 340-, 440-, and 500-cm-1 Raman modes of YBa2Cu3Oy for 6.7 <~ y <~ 7.0. Physical Review. B, Condensed Matter 47(13): 8140-8150

Wu, D.; Talbot, C.Conover.; Liu, Q.; Jing, Z-Cheng.; Damico, R.L.; Tuder, R.; Barnes, K.C.; Hassoun, P.M.; Gao, L., 2016: Identifying microRNAs targeting Wnt/β-catenin pathway in end-stage idiopathic pulmonary arterial hypertension. MicroRNAs (miRNAs) play important roles in the pathogenesis of pulmonary arterial hypertension (PAH). However, the pathways targeted by miRNAs in PAH have not been systematically investigated. We aim to identify dysregulated miRNAs for patients wi...

Jiménez, V.Alfonso.; Sepúlveda, J.; Ponce, Jé.; Baz, Jé.Antonio.; Iñiguez, Aés., 2015: It's just a coronary milking-like effect … or maybe not: posterolateral artery compression caused by a ventricle pseudoaneurysm. European Heart Journal Cardiovascular Imaging 15(11): 1193-1193

Vallet, M.; Tran, N.H.; Tanguy, P.; Floch, A.L.; Bretenaker, F., 1994: Ring-laser gyro with spatially resolved eigenstates. The spatial resolution of laser eigenstates is applied to ring geometry. A bidirectional optical diode based on the Faraday effect and nonreciprocal intracavity losses is theoretically and experimentally investigated. This novel optical diode comb...