geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A serogroup A meningococcal polysaccharide vaccine: studies in the Sudan to combat cerebrospinal meningitis caused by Neisseria meningitidis group A


, : A serogroup A meningococcal polysaccharide vaccine: studies in the Sudan to combat cerebrospinal meningitis caused by Neisseria meningitidis group A. Bulletin of the World Health Organization 49(3): 301-305

Vaccination against cerebrospinal meningitis (CSM) has regained interest with the use of capsular polysaccharides (or polyosides) of the meningococcus as specific immunizing agents. These compounds proved to be effective in the USA against meningitis caused by Neisseria meningitidis serotype C. This study considers whether the polysaccharides of the serotype A meningococcus, which is prevalent in the African CSM belt, could be protective in epidemic conditions. Taking advantage of the usual seasonal peak of CSM cases, controlled field trials were undertaken in the Sudan early in 1973. 21 640 persons were vaccinated, half of them with a meningococcal polyoside A vaccine and the other half with tetanus toxoid as a placebo. In the former group there were no cases of meningitis, whereas in the latter 10 cases were reported, of which 7 were confirmed by laboratory tests. These studies indicate that the meningococcal polyoside A vaccine is efficient in epidemic conditions and could be used to control outbreaks of meningococcal meningitis.

US$29.90

PMID: 4211056


Other references

Snider, R.S.; Cooke, P.M., 1954: Cerebral seizures as influenced by cerebellar stimulation. The present study on alteration of electrically produced cerebral seizures by cerebellar stimulation supports the concept of widespread cerebellar projections to sensory and motor areas of the cerebrum and sensory relay nuclei of the thalamus plus...

Tatem, C.E.; Dorer, R.E., 1974: A year's experience with ULV fogging in Virginia. Ultra-low-volume non-thermal aerosols of malathion dispersed from a Leco and a locally made generator were found to be equally effective for control of adult mosquitos in Virginia in 1971. The generators were operated from trucks moving at 10 mile...

Grimm W D., 1984: Prevention as a complex acting strategy of stomatologic care in the adult. The key to the prevention of caries and of periodontal diseases lies in the etiology. Therefore, practical proven prevention possibilities rest on a uniform conception of plaque control for the reduction of enamelodemineralization and of the phlog...

Smith, R.E.; Bowman, J.N., 1961: Wheat rust during the Spanish era in California. With respect to plant diseases in the Spanish era in California, most of the priests and explorers who left behind their mission records, diaries, and descriptions of their travels apparently recognized only 1. This was wheat rust, or chauistle as...

Anonymous, 2012: Positive / negative perfectionism and perceived quality of life in Psychology, Medicine and Engineering students of the city of Buenos Aires. El objetivo del presente estudio es dar cuenta de la relaci n entre el perfeccionismo en sus tres dimensiones (Altos Est ndares -AE-, Orden -O- y Discrepancia-D-) y la calidad de vida percibida (CV) en tres muestras de estudiantes universitarios d...

Pomerantz, M.Lucius., 2016: Complications of Lateral Epicondylar Release. Reported complication rates are low for lateral epicondylitis management, but the anatomic complexity of the elbow allows for possible catastrophic complication. This review documents complications associated with lateral epicondylar release: 67 s...

Ansar, S.; Alhefdhi, T.; Aleem, A.M., 2016: Status of trace elements and antioxidants in premenopausal and postmenopausal phase of life: a comparative study. The aim of the study was to determine the extent of free radical damage in the form of oxidative stress, the antioxidant status and correlate with trace element levels in postmenopausal females as compared to premenopausal females. Participants be...

Matousek, M., 1951: Achievements of medicine. Casopis Lekaru Ceskych 90(11): 344-345

Singh D.P., 1986: Nitrate transport in the mutants of anacystis nidulans exhibiting alterations in cyanophage as 1 adsorption methylene blue uptake and drug sensitivity. .**GRAPHIC**. uptake exhibited Michaelis-Menten type kinetics with saturation point at 90 .mu.M of .**GRAPHIC**. Lineweaver-Burk plot of the data showed an apparent Km of 250 .mu.M and Vmax of 12.5 nmol mg-1 protein min-1; this suggests the existe...

Chugh, K.S., 1992: Glomerular disease in the tropics. Journal of the Association of Physicians of India 40(4): 215-222