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A serotonergic component of [3H] N-acetylserotonin binding in mammalian brain


, : A serotonergic component of [3H] N-acetylserotonin binding in mammalian brain. Progress in Neuro-Psychopharmacology & Biological Psychiatry 6(4-6): 421-424

1. Evidence that the putative pineal hormone, N-acetylserotonin (NAS) and its synthesizing enzyme, N-acetyltransferase (NAT) are present in various brain areas, prompted a study of its binding characteristics in CNS tissue. 2. In fresh rat brain membranes, tritiated N-acetylserotonin ([3H]NAS) appeared to bind to a single population of high affinity sites with an equilibrium dissociation constant (Kd) of 3-5nM, whereas in frozen tissues from rat, calf and human brain high and low affinity binding site classes were present. 3. Inhibition experiments indicated that NAS and serotonin (5-HT) were the most potent inhibitors of [3H]NAS binding in the rat frontal cortex and cerebellum. The 5-HT agonist, quipazine, and various 5-HT antagonists, including the 5-HT2 antagonist, ketanserine, also inhibited binding with moderate affinity in the frontal cortex. 4. These findings suggest that [3H]NAS labels both 5-HT1 and 5-HT2 sites in the rat Brain.

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PMID: 6891808


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El-Sayed, W.; Aboul-Fadl, T.; Lamb, J.G.; Roberts, J.C.; Franklin, M.R., 2006: Acute effects of novel selenazolidines on murine chemoprotective enzymes. Novel selenazolidines, designed as L-selenocysteine prodrugs and potential cancer chemopreventive agents, were examined for their ability to affect the transcription of murine hepatic chernoprotective enzymes. Compounds investigated were selenazol...

Prewett, R., 1987: Texas faces crisis on Mexican fruit fly program. The costs of the sterile-insect release programme for the control of Mexican fruit fly [Anastrepha ludens] in Texas are discussed in relation to the costs to the Citrus industry that would arise should the programme be discontinued for economic re...

Streel M., 1985: Devonian spore biostratigraphy of the Ardennes and Rhenish Schiefergebirge. Annales de la Societe Geologique du Nord 105: 85-95

Najman, Y., 2008: The Paleogene record of Himalayan erosion, Bengal Basin, Bangladesh; implication for coupling between erosion, tectonics and marine geochemistry. Geophysical Research Abstracts 10

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Boulet, P.C., 1963: Experimental and comparative study of the visual perception of movement and predatory behavior in a fish , a cephalopod , and an insect Abstract only. Proc Internatl Congr Zool 16(2): 11

Patterson, R.L.; Lockhart, L.B., 1964: Geographical distribution of lead-210 in the ground-level air. Short-term measurements of lead-210 in the air cannot suffice to define its average activity concentration in any area. Moreover, the lead-210 is a given air parcel at ground level bears little relation to the radon-222 in the same sample, since t...

Plassman, E., 1981: Mycomyia lindrothi n. sp. and Anatella laffooni Plassm., two new fungus gnats (Diptera: Mycetophilidae). M. lindrothi sp. nov. and A. laffooni Plassm., 1977, belonging to the family Mycetophilidae, are described and figured. M. lindrothi was collected in the Alps of Tyrol, Austria, and A. laffooni is known from the small stream Kaltisjokk near Messau...

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Schacht, H., 1871: Unsere Hohlenbruter. Zoologische Garten, 129-137, 175-183, 201-204