+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A serotonin agonist-antagonist reversible effect on Na+-K+-ATPase activity in the developing rat brain

, : A serotonin agonist-antagonist reversible effect on Na+-K+-ATPase activity in the developing rat brain. Developmental Neuroscience 5(4): 326-331

In brain of adult and developing rats the Na+-K+-adenosine triphosphatase (Na+-K+-ATPase) system seems to react to serotonin (5-HT) changes induced pharmacologically. A 5-HT agonist (quipazine) elicits a response of the enzyme activity in the cerebral cortex in vivo, which is neutralized with a 5-HT antagonist (methysergide). This effect was observed from day 21 to adulthood. Also in a state of 5-HT receptor hypersensitivity (rats treated early with 5,6-dihydroxytryptamine), the response of Na+-K+-ATPase to the 5-HT agonist was higher than without neurotoxic lesion of 5-HT paths. These data suggest an involvement of the Na+-K+-ATPase system in 5-HT receptor sensitivity in the rat brain.


PMID: 6291893

Other references

Andersen, C.Beyschau.; Otzen, D.; Christiansen, G.; Rischel, C., 2007: Glucagon amyloid-like fibril morphology is selected via morphology-dependent growth inhibition. The 29-residue peptide hormone glucagon readily fibrillates at low pH, but the structure and morphology of the fibrils are very sensitive to the environmental conditions. Here we have investigated the mechanism behind the differences in morpholog...

Karthik, R., 2008: Infectious causes of macrophage activation syndrome. Journal of the Association of Physicians of India 55: 877-878

Tauzin Fin, P.; Delort Laval, S.; Krol Houdek, M.C.; Maurette, P.; Bannwarth, B., 1998: Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures. The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia. Two hundred and ni...

Uchijima, Y.; Hiraga, S.; Negishi, T., 1985: Studies of human lactate dehydrogenase-x (C4) [LDH-X(C4)]. 1. Purification of human LDH-X(C4). Nihon Hinyokika Gakkai Zasshi. Japanese Journal of Urology 76(4): 546-553

Barrios, C.; Bernardo, N.D.; Vera, P.; Laíz, C.; Hadala, M., 2015: Changes in sports injuries incidence over time in world-class road cyclists. This is a descriptive epidemiologic survey on all traumatic and overuse injuries which occurred in 2 groups of male elite road cyclists based on retrospective clinical interviews and physical examinations. The historical group consisted of 65 prof...

Hilgard, E.R., 1969: Altered states of awareness. Journal of Nervous and Mental Disease 149(1): 68-79

Morton, H.E.; Engley, F.B., 1945: The Protective Action of Dysentery Bacteriophage in Experimental Infections in Mice. Dysentery bacteriophage shows good protection, prophylactically and therapeutically, against experimental infections in mice produced by Shigella paradysenteriae Flexner. Dysentery-phage exerts a prophylactic action when given as long as 7 days pr...

Khanna S.M.; Banerjee S.K., 1985: Colorimetric estimation of hydrocortisone. Colorimetric method for the estimation of hydrocortisone (HC) is based on the oxidation of .alpha.-ketol side chain with ceric ammonium nitrate is described. The (HC) concentration is determined on the basis of cerium reacted with the (HC), which...

Shysh, A.J.; Eagle, C.J., 1997: The characteristics of excellent clinical teachers. Canadian Journal of Anaesthesia 44(6): 577-581

Caelli, T.; Finlay, D., 1979: Frequency, phase, and colour coding in apparent motion. We present some results which indicate that the known spatiotemporal limits for apparent motion are consistent with the motion being sinusoidal or a result of filtering. Given this we investigated how two such motions interact as a function of the...