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Abnormal electrocardiographic activity revealed by isolated rat heart preparations at various times after experimental myocardial infarction


, : Abnormal electrocardiographic activity revealed by isolated rat heart preparations at various times after experimental myocardial infarction. Cardiovascular Research 15(3): 144-150

Experimental myocardial infarction has been induced in rats by isoprenaline pretreatment and progress of the lesions has been observed histologically at intervals over a period of 6 weeks. This revealed transition from extensive ischaemic degeneration to apparently complete recovery of much of the affected muscle, leaving lesser areas of necrotic cells to become replaced by dissecting collagen-fibre scars. Isolated perfused preparations of affected and normal hearts were used to give electrocardiogram records. Oscilloscope photographs were measured. Ischaemia was associated, typically, with enlarged Q waves and decreased R and S waves, plus evidence of bundle branch block. These abnormalities abated as lesions resolved, leaving residual Q enlargement and arrhythmias, consistent with persistent scarring.

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PMID: 7260982


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