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Action of hydrolyzed cisplatin and some analogs on microtubule protein polymerization in vitro

, : Action of hydrolyzed cisplatin and some analogs on microtubule protein polymerization in vitro. Cancer Treatment Reports 67(7-8): 641-646

The inhibition of tubulin microtubule polymerization by cisplatin was investigated. The interaction was monitored by turbidity measurements and electron microscopy. For a 2.5 x 10(-5) M concentration of cisplatin, the inhibition at 37 degrees C was nearly 50% after 1 hour of incubation and 80% after 2 hours. A similar but lesser effect was observed after incubation at 4 degrees C. One analog of cisplatin, sulfato-aqua(1,2)diamminocyclohexane platinum II, showed the same inhibition effect.


PMID: 6683590

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Wiant, J.S., 1939: Species of Phytophthora responsible for market decay of Western Honey Dew Melons and Cantaloups. All but one of eleven representative isolates of Phytophthora from decaying Honey Dew melons and cantaloupes on the New York market in September, 1938, were determined as P. capsici . One isolate from a cantaloupe from Green River, Utah, was found...