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Activity of sequential low-dose methotrexate and fluorouracil in advanced colorectal carcinoma: attempt at correlation with tissue and blood levels of phosphoribosylpyrophosphate


, : Activity of sequential low-dose methotrexate and fluorouracil in advanced colorectal carcinoma: attempt at correlation with tissue and blood levels of phosphoribosylpyrophosphate. Journal of Clinical Oncology 2(4): 311-315

Forty-five patients with metastatic colorectal carcinoma were treated with low-dose methotrexate (MTX) and 5-fluorouracil (5-FU) given sequentially. The dose of MTX was 40 mg/m2 intravenously (IV) on days 1 and 8 followed 24 hours later by 5-FU at 600 mg/m2 IV on days 2 and 9; the drugs were recycled every 28 days. Fourteen (32%) of 43 adequately treated patients had a complete or partial response lasting a median of nine months (range, 6-15 + months). Four patients had a minor response and seven patients had stable disease for a median of nine and 10 months, respectively. Toxicity included mucositis in 28 (65%) patients, diarrhea in 18 (40%), nausea in 11 (24%), and vomiting in seven (16%). Hematologic toxicity was mild: six patients had nadir white blood cell counts less than 3.5 X 10(3) cells/microL, and seven patients had a nadir platelet count less than 100 X 10(3) cells/microL. Serial biopsies and blood samples were obtained in selected patients to evaluate the effect of MTX on tissue and lymphocyte phosphoribosylpyrophosphate (PRPP) and PRPP synthetase levels.

US$19.90

PMID: 6200577

DOI: 10.1200/jco.1984.2.4.311


Other references

Nason, W.A., 1906: A new subspecies of Polygyra multilineata Say. Nautilus Boston Mass, 19 141-142

Bushmelev, V.A., 1963: On The Differential Diagnosis And Treatment Of Rectal Polyps In Children. Voprosy Okhrany Materinstva i Detstva 8: 35-39

Dougherty, C.M.; Reiner, I., 1959: Complications and sequelae of hydatidiform mole. A series of 65 cases of hydatidiform mole occurring in private and charity patients was studied.

Liu, M.C., 1993: Factors affecting induction, somatic embryogenesis and plant regeneration of callus from cultured immature inflorescences of sugarcane. Immature inflorescence segments of sugarcane (Saccharum spp. hybrids) breeding lines were cultured on several versions of MS based media containing various concentrations and combinations of 2,4-D, kinetin, BAP, CH and calcium pantothenate. The ex...

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Gallagher, P.G.; Tse, W.T.; Costa, F.; Scarpa, A.; Boivin, P.; Delaunay, J.; Forget, B.G., 1991: A splice site mutation of the beta-spectrin gene causing exon skipping in hereditary elliptocytosis associated with a truncated beta-spectrin chain. We studied a French kindred with hereditary elliptocytosis associated with a spectrin variant (spectrin LePuy) containing a beta-spectrin chain that is truncated at its C terminus (Dhermy, D., Lecomte, M., Garbarz, M., Bournier, O., Galand, C., Ga...

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