geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Acute leukemia and pregnancy: a review of management and outcome, 1972-1982


, : Acute leukemia and pregnancy: a review of management and outcome, 1972-1982. Obstetrical & Gynecological Survey 39(11): 663-678

Acute leukemia is a rare complication of pregnancy. Previous reviews that covered cases reported before the introduction of effective combination chemotherapy found fewer than 300 reported pregnancies, with a 36-69 per cent perinatal mortality and median maternal survival, from diagnosis, of less than 6 months. Advances in the fields of hematology-oncology, maternal-fetal medicine, and neonatology have resulted in a marked improvement in both perinatal survival statistics, and median maternal survival. Since 1972, there have been 14 pregnancies reported in patients cured of acute lymphocytic leukemia, with 1 early spontaneous abortion and 13 term infants. All mothers survived. There have been 47 reports of pregnancy in association with acute leukemia. In 40 pregnancies in which acute leukemia was treated, there were 5 abortions, 3 perinatal demises, 1 infant "liveborn in grave condition," and 31 surviving infants. Median maternal survival was at least 6, and possibly more than 12 months from delivery. In seven cases in which leukemia was untreated, there were one abortion, two perinatal demises, and four living infants; only one of six mothers survived beyond 6 months. Here, a case of pregnancy complicated by acute promyelocytic leukemia is presented. The mother was aggressively treated with combination chemotherapy. The fetus was closely monitored and delivered following a course of betamethasone at 34 weeks' gestation, and had no neonatal problems. The mother expired 13 months status-post bone marrow transplantation, 16 months after delivery. Cases of pregnancy complicated by acute leukemia reported in the period 1972-1982 are reviewed, and management is discussed in detail. Aggressive hematologic and obstetric management is advocated, and should result in further improvements in fetal and maternal outcome.

US$29.90

PMID: 6390276


Other references

Steponkus, P.L., 2002: Peter L. Steponkus memorial issue. Cryo Letters 22(6): 337-396

Shivakumar, B.G.; Mishra, B.N.; Gautam, R.C., 2004: Nutrient economy through land configuration and residue management in a greengram (Phaseolus radiatus L.)-wheat (Triticum aestivum L.) cropping sequence with limited water supplies. A field experiment on a greengram-wheat cropping sequence was carried out under limited water supply conditions in 1997-98 and 1998-99 at the farm of the Indian Agricultural Research Institute, New Delhi. The greengram was sown either on flat beds...

Bender, A.S.; Wu, P.H.; Phillis, J.W., 1981: The rapid uptake and release of [3H]adenosine by rat cerebral cortical synaptosomes. Adenosine, a putative inhibitory transmitter or modulator in the brain, is rapidly transported by rat cerebral cortical synaptosomes. The uptake may represent a facilitated diffusion process, which is saturable and temperature-dependent. In this s...

Anonymous, 1971: The place of agriculture in industrial society. The principal contributions to the XXII Assembly of the European Confederation of Agriculture, held in Florence in October, 1970 are summarized. The main paper was: the general role of agriculture and forestry and their irniportance for modern ind...

Grigoriants, A.N.; Levina, S.I.; Khmelnitskaia, A.B., 1963: Rupture Of The Heart In Myocardial Infarct. Terapevticheskii Arkhiv 35: 77-82

Mahon, B.D.; Gordon, S.A.; Cruz, J.; Cosman, F.; Cantorna, M.T., 2003: Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month v...

Bouchardeau, F.; Chauveau, P.; Bonete, R.; Zins, B.; Naret, C.; Lemarrec, N.; Poignet, J.L.; Courouce, A.M., 1994: Detection of HCV-RNA in hemodialysis patients in relationship to anti-HCV status by third generation test. Journal of the American Society of Nephrology 5(3): 435

Sanati, A.; Haeri, F.H.; Azordegan, F.; Pourbahador, R.; Firouzi, K.; Lotfiani, F., 1998: Immediate response of pulmonary vascular bed to PTMC and its relation to basal pulmonary artery pressure. European Heart Journal 19(ABST SUPPL ): 531, Aug

Badini, K.B.; Nader Filho, A.; Amaral, L.A. do, 1997: Consumption of clandestinely produced and marketed raw milk in Botucatu and Sao Manuel, SP. A survey of 60 families who habitually consumed raw milk clandestinely produced and sold in Botucatu and Sao Manuel, SP, Brazil showed that 70% considered that it had a superior quality to pasteurized milk. This was attributed by 73.3% to the addi...

Hoess R.H.; Herman R.K., 1974: Frameshift mutator genes of escherichia coli. Abstracts of the Annual Meeting of the American Society for Microbiology 74: 48