+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Age-related changes in brain RNA of noise stressed mice

, : Age-related changes in brain RNA of noise stressed mice. Neurobiology of Aging 2(2): 143-147

Correlative data were obtained on RNA levels of cerebrocortical neurons, adrenal fasciculate cell RNA content and serum corticosterone levels in 10, 40 and 100 week old male C57BL/6J mice immediately following a 30 interval of continuous noise stimulation (100 dB re 2 x 10(-5) N/m2, 0.35-20 kHz) and at 1 hr and 4 hr recovery intervals. Quantification of cellular RNA levels entailed use of scanning-integrating microdensitometry of azure B stained tissue sections. Hormonal analyses were done by radioimmunoassay. Noise stimulation induced a mild to moderate adrenocortical activation and a moderate elevation of serum corticosterone levels in all age groups. Noise exposure also resulted in an increase in the RNA content of cerebrocortical neurons. However, maximal neuronal RNA levels proved to be considerably lower (32-36%) in 100 week old mice as compared to both 10 and 40 week old mice during the post-exposure intervals. The overall data support the existence of a lower neuronal capacity for sensory induced RNA synthesis in 100 week old mice. The data also suggest that age dependent differences in neuronal responsiveness are not directly related to the extent of adrenal RNA activation or to a lower availability of circulating glucocorticoids.


PMID: 6170904

Other references

Harmon, C.S.; Nevins, T.D., 1994: Hair fibre production by human hair follicles in whole-organ culture. We have used both pulse-chase radiolabelling and morphometric techniques to investigate the ability of whole-organ cultures of human hair follicles to synthesize hair fibre. Anagen hair follicles were obtained from human facial skin by microdissec...

Gulland, A., 2002: BMA steps up call for ban on smoking in public places. Bmj 325(7372): 1058-1058

Tintle, S.M.; Gwinn, D.E.; Andersen, R.C.; Kumar, A.R., 2010: Soft tissue coverage of combat wounds. Warfare-related open fractures with large soft tissue defects create a significant reconstructive challenge. The objective of this article is to review current and evolving treatment strategies for soft tissue coverage of warfare-induced extremity...

Kim, J.Hyung.; Park, K.Suk.; Yi, S.; Shin, H.Chul.; Yoon, D.Heum.; Kim, K.Nyun., 2005: Real-time CT fluoroscopy (CTF)-guided vertebroplasty in osteoporotic spine fractures. The purpose of this study was to evaluate the clinical feasibility, benefits, and limitations of CT fluoroscopy (CTF)-guided percutaneous vertebroplasty (PVP). PVP under the guidance of CTF without additional guidance by conventional C-arm fluoros...

Kunz, Kriton, 2004: Schlangensymbolik im Totenbuch der Aegypter. Draco 5(1): 54-63 Nr 17

Bozdogan, G.; Erdem, E.; Demirel, G.Yanikkaya.; Yildirmak, Y., 2011: The role of Treg cells and FoxP3 expression in immunity of β-thalassemia major AND β-thalassemia trait patients. There is increased susceptibility to infections in β-thalassemia. Changes in T- and B-lymphocyte subsets and functions, defective chemotaxis, and phagocytosis of neutrophils and macrophages have been described in these patients. Regulatory T cell...

Holthuis, L.B., 1964: The genus Astacoides Guerin (Decapoda Macrura). Crustaceana, 6: 309-318

Lanza, D., 1926: History of the development of biology in Sicily. Atti Del Ii Congr Naz Di Chim Pura Ed Applicata Palermo Maggio : 1457-1581

Sergeev, A.S., 1980: Analysis of phenotypic correlations between qualitative characters 2. estimation of contribution of the nominal factor into variation of susceptibility to multi factorial diseases. A method for the evaluation of the determination coefficient which estimates the contribution of the nominal factor (X) into the variability of multifactorial trait (Y) in the traditional terms of variance is proposed. To construct the coefficient...

Jiang, S.; Eberhart, C.G.; Zhang, Y.; Heo, H-Young.; Wen, Z.; Blair, L.; Qin, H.; Lim, M.; Quinones-Hinojosa, A.; Weingart, J.D.; Barker, P.B.; Pomper, M.G.; Laterra, J.; van Zijl, P.C.M.; Blakeley, J.O.; Zhou, J., 2017: Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas. Pathological assessment using World Health Organization (WHO) criteria is the gold standard for diagnosis of gliomas. However, the accuracy of diagnosis is limited by tissue sampling, particularly for infiltrating, heterogeneous tumours. We assess...