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Amantadine hydrochloride pharmacokinetics in hemodialysis patients


, : Amantadine hydrochloride pharmacokinetics in hemodialysis patients. Annals of Internal Medicine 93(1): 46-49

To study the fate of amantadine hydrochloride in patients with renal failure, we gave 100 mg orally to 12 such patients immediately after hemodialysis. Plasma levels did not decrease between 24 and 44 hours after drug ingestion, suggesting an extremely poor total body clearance. Apparent volume of distribution was 5.1 +/- 0.2 (SEM) L/kg of body weight. Between 44 and 48 hours, as a result of 4 hours of hemodialysis, the mean plasma drug level decreased from 268 to 225 ng/mL (P less than 0.001). Dialyzer clearance was 67.0 +/- 3.9 mL of plasma per minute. The total quantity of drug removed by the dialysis treatment, however, was only 3.9 +/- 0.25 mg. The average half-life of amantadine in eight patients studied while receiving maintenance hemodialysis was 24.3 +/- 2.4 h of dialysis administered over approximately 13 days. Plasma half-life in six nonuremic control subjects was 12.2 +/- 1.6 h. Amantadine is poorly excreted in dialysis patients and has a large volume of distribution. The amount removed by a single dialysis is only a small fraction of the total body store.

US$29.90

PMID: 7396313


Other references

Schumann, H., 1982: The importance of the Musca domestica natural enemy Ophyra aenescens (Diptera: Muscidae). II. Morphology of the developmental stages. The egg, 1st-, 2nd- and 3rd-instar larva and pupa of Ophyra aenescens are described. Its morphological features indicated that the larvae are semi-carnivorous, and it is considered to be an efficient natural enemy of Musca domestica.

Plein, A.; Calmont, Aélie.; Fantin, A.; Denti, L.; Anderson, N.A.; Scambler, P.J.; Ruhrberg, C., 2015: Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation. In mammals, the outflow tract (OFT) of the developing heart septates into the base of the pulmonary artery and aorta to guide deoxygenated right ventricular blood into the lungs and oxygenated left ventricular blood into the systemic circulation....

Sellenschlo, Udo., 2004: 170 Col Dermestidae - a further record of Thylodrias contractus Moschulsky, 1839, in Hamburg 170 Col Dermestidae - Weiterer Fund von Thylodrias contractus Moschulsky, 1839, in Hamburg. Bombus. 1 Oktober; 364-65: 259

Van Meirvenne, M.; Pannier, J.; Hodman, G.; Louwagie, G., 1996: Regional characterization of the long-term change in soil organic carbon under intensive agriculture. To study the change in soil organic carbon (SOC) since it was recorded during the Belgian National Soil Survey some 40 years ago, we recently revisited 939 locations still under use as arable land. The study area comprised almost the entire provin...

Reagan, J.D.; Li, J.P.; Carney, R.L.; J.Kramer, S., 1993: Characterization of a diuretic hormone receptor from the tobacco hornworm, Manduca sexta. We have characterized a diuretic hormone receptor from the tobacco hornworm, Manduca sexta. A single high affinity binding site for the 41 amino acid M. sexta diuretic hormone was found in membranes prepared from Malphighian tubules of fifth stadi...

O'Leary, M.J.; Xue, A.; Scarlett, C.J.; Sevette, A.; Kee, A.J.; Smith, R.C., 2007: Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis. Premature circuit clotting is a major problem in daily practice of continuous renal replacement therapy (CRRT), increasing blood loss, workload, and costs. Early clotting is related to bioincompatibility, critical illness, vascular access, CRRT ci...

Ban, R.W.; Stowell, E.C., 1956: Production of ergothioneine by Claviceps purpurea in defined culture. Results obtained using paper and alumina chromatography establish the presence of ergothioneine in the mycelium of C. purpurea cultured on a defined medium in concentrations comparable to that found in ergot sclerotia. The content of ergothioneine...

Buckhouse J.C., 1992: Livestock impacts on stream water quality. Bulletin of the Ecological Society of America 73(2 SUPPL): 128

Engelmann, L.; Kunze, J., 1990: Multiple trichoepitheliomas. We report on a 27-year-old male patient suffering from multiple trichoepitheliomas, which first appeared on his face at the age of 15 and later spread to his upper extremities and back. Multiple trichoepitheliomas are benign tumors of the skin app...

Karapetyan, V.K., 1972: Biological characteristics of development of alternative wheats. The alternative variety Galgalos of Triticum aestivum acquired the winter habit and cold resistance after it had been grown as a winter variety for 4-5 generations under Moscow conditions. It did not ear when spring sown but overwintered well when...