+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Anesthetic depression of microcirculation, central hemodynamics, and respiration in decerebrate rats

, : Anesthetic depression of microcirculation, central hemodynamics, and respiration in decerebrate rats. American Journal of Physiology 243(6): H837-H843

The objectives of this study were the development of a skeletal muscle microcirculatory preparation, in which the complications of drug anesthesia were minimized, and the quantitation of the effects of urethan and chloralose anesthesia on the microcirculation. Rats were initially anesthetized with urethan and chloralose and decerebrated by a midcollicular transection. The cremaster skeletal muscle, with intact circulation and innervation, was prepared for intravital microscopy by placement in a tissue bath. Arterioles (9-70 micrometers diam) at several anatomic levels were observed during the initial period of urethan-chloralose anesthesia (period 1), after recovery from the anesthesia (period 2), and again following reanesthetization (period 3). During period 2, respiratory rate, heart rate, and mean arterial pressure were significantly greater than during periods 1 and 3. Smaller arterioles (8-50 micrometers diam) exhibited vasomotion (mean amplitude 35% of mean diameter; mean frequency 31 cycles/min) during period 2. Urethan-chloralose anesthesia during periods 1 and 3 inhibited vasomotion and increased arteriolar diameters by 16-36%. This study quantitates the depressant effects of urethan-chloralose anesthesia on the cardiovascular system and demonstrates the feasibility of using decerebration to circumvent the necessity of continuous drug anesthesia for in vivo microvascular studies.


PMID: 7149040

Other references

Opinion 616,, 1961: Tanytarsus van der Wulp, 1874 (Insecta, Diptera); designation of a type-species under the Plenary Powers. Bull Nom., London: 361-362

Thijssen, H.H.; Baars, L.G.; Hazen, M.J.; Van den Bogaard, A.E., 1984: The role of the intestinal microflora in the reductive metabolism of acenocoumarol in man. Although the oral anticoagulant acenocoumarol (AC) is very effectively metabolized by the intestinal microflora to its amino metabolite, under clinical conditions this route of AC-disposition is of no importance because the compound is rapidly abs...

Gilbertson, L.M.; Albalghiti, E.M.; Fishman, Z.S.; Perreault, Fçois.; Corredor, C.; Posner, J.D.; Elimelech, M.; Pfefferle, L.D.; Zimmerman, J.B., 2016: Shape-Dependent Surface Reactivity and Antimicrobial Activity of Nano-Cupric Oxide. Shape of engineered nanomaterials (ENMs) can be used as a design handle to achieve controlled manipulation of physicochemical properties. This tailored material property approach necessitates the establishment of relationships between specific ENM...

Conrad, A.H.; Stephens, A.P.; Paulsen, A.Q.; Conrad, G.W., 1993: Effects of silver ions (Ag+) on first cleavage in Ilyanassa obsoleta embryos. Bulletin of the Mount Desert Island Biological Laboratory. March; 32: 2-3

Uzümcügil, O.; Atici, Y.; Ozturkmen, Y.; Yalcinkaya, M.; Caniklioglu, M., 2013: Evaluation of shoulder balance through growing rod intervention for early-onset scoliosis. Retrospective clinical study. To compare the single and dual growing rod techniques with an emphasis on shoulder balance in the surgical treatment of early-onset scoliosis. In the literature, there exist not much data about shoulder balance throug...

Iordanishvili, A.K.; Soldatov, S.V.; Moskalev, A.V.; Soldatova, L.N.; Ryzhak, G.A., 2012: Characteristics of paradontal recesses microbiocenosis and immune homeostasis in patients of elderly and senile age with chronic generalized periodontitis. The microbiocenosis of periodontal recesses was studied and an assessment of the innate immunity mechanisms, as well as profiles of inflammatory cytokines were carried out in 114 people of middle, elderly and senile age with chronic generalized pe...

Oda K., 1976: Sv 40 induction of protein synthesis controlling factor. Virus (Nagoya) 26(1-2): 47-48

Bailey, Allen J., 2001: Molecular mechanisms of ageing in connective tissues. The outward manifestations of tissue ageing occurring in the elderly primarily involve the two major structural proteins of the body, collagen and elastin. The changes in these proteins are associated with intermolecular cross-linking and side-cha...

Osei, K.; Falko, J.M., 1985: Serum C-peptide levels determine glycemic responses in type II diabetic patients treated with combined insulin and sulfonylurea agent. Type II diabetes mellitus is a heterogeneous disease. Selection of either insulin or a sulfonylurea agent in addition to diet is usually made empirically. In patients who fail to respond to either agent alone, the potential benefit of combined ins...

Houben, K.; Nederkoorn, C.; Higgs, S., 2017: An introduction to the special issue on 'Executive function training & eating behaviour'. Appetite