+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Anti-hypertensive action of labetalol: a detailed profile

, : Anti-hypertensive action of labetalol: a detailed profile. Australian and New Zealand Journal of Medicine 12(5): 467-472

Continuous, ambulatory blood pressure (BP) and self measured home recordings were used to study the response of ten mild to moderate hypertensives taking a twice daily labetalol dosage. Testing of cardiovascular reflexes was carried out 12 hours after a dose of drug. The mean 24 hour BP was reduced from 145/80 +/- 14/7 (SD) mmHg to 130/71 +/- 11/6 (p less than 0.001) and home BP from 147/96 +/- 15/9 to 134/84 +/- 10/9 (p less than 0.01). The predominant effect of labetalol was evident during the waking hours. A residual 9.5% BP reduction was seen 12 hours after a dose compared to an 11% lowering effect over the entire 24 hours (NS). No symptomatic hypotensive episodes were noted. Significant inhibition of heart rate and BP rise during dynamic exercise (p less than 0.01) and reduction of post-release BP "overshoot" (p less than 0.01) in Valsalva's manoeuvre indicated a beta adrenoceptor blocking effect. There was however a reduction in the rate of rise of BP during static handgrip (p less than 0.01) indicating a small alpha adrenoceptor blocking component. This study has demonstrated the efficacy of a twice daily regimen of labetalol in continuously lowering BP. The mode of action of the drug during exercise (static and dynamic) and Valsalva's manoeuvre would indicate a predominant beta adrenoceptor blocking action.


PMID: 6758743

Other references

Espadaler X.; D.M.rle P., 1989: Leptothorax fuentei new record santschi 1919 in france hymenoptera formicidae. Leptothorax fuentei Santschi is recorded for the first time in France. Known localities for this species are indicated.

Matthews, P., 1979: Familial Dupuytren's contracture with predominantly female expression. A family pedigree is described in which a strong Dupuytren's trait is manifest predominantly on the female side. The genetic aspects of the condition are reviewed and the importance of gene penetrance is stressed.

Muztar, A.J.; Slinger, S.J.; Burton, J.H., 1976: Nutritive value of aquatic plants for chicks. Male chickens of an egg strain were given from day-old to 4 weeks of age diets based on maize and soya bean oilmeal alone for controls or with 2.5, 5 or 10% lucerne or dried fresh water plants. The plants were algae (Cladophora), pondweed (Potamog...

Hemminki, K.; Vauhkonen, M., 1977: Distribution of estrogen receptors in hen oviduct chromatin fractions in the course of DNAase II digestion. Hen oviduct chromatin was digested with DNAase II and two fractions were isolated: MgCl2-insoluble chromatin and MgCl2-soluble chromatin. The former contained 14 and 50% of the total DNA after a digestion time of 3 and 30 min, respectively. The fr...

Brunschwig, A.; Pierce, V.K., 1950: Partial and complete pelvic exenteration; a progress report based upon the first 100 operations. Cancer 3(6): 972-974

Oliveira E.G.D.; Morais J.O.F.D., 1989: Influence of dilution rate on the productivity and yield of continuous alcoholic fermentation with zymomonas mobilis. Continuous alcoholic fermentation trials with Zymomonas mobilis Z-1-81 indicated that the best utilization of the substrate was showed using a dilution rate of 0,095 h-1 in the steady state. In these conditions the fermentation yield and ethanol p...

Amantini, D.; Fringuelli, F.; Piermatti, O.; Pizzo, F.; Zunino, E.; Vaccaro, L., 2005: Synthesis of 4-aryl-1H-1,2,3-triazoles through TBAF-catalyzed [3 + 2] cycloaddition of 2-aryl-1-nitroethenes with TMSN3 under solvent-free conditions. TBAF-catalyzed [3 + 2] cycloaddition reactions of 2-aryl-1-cyano- or 2-aryl-1-carbethoxy-1-nitroethenes 1 with TMSN3 under SFC allow the corresponding 4-aryl-5-cyano- or 4-aryl-5-carbethoxy-1H-1,2,3-triazoles 2 to be prepared under mild reaction c...

Park, S.Wook.; Kang, M.Ran.; Eom, H.Seok.; Han, J.Youn.; Ahn, C.Hyeok.; Kim, S.Soo.; Lee, S.Hyung.; Yoo, N.Jin., 2010: Somatic mutation of PIK3R1 gene is rare in common human cancers. Acta Oncologica 49(1): 125-127

Anonymous, 1982: Papers, International Symposium Polders of the world. Lelystad, the Netherlands, 1982. (3 vols.). Volume 1 contains the papers dealing with specific polder projects and with land and water management aspects; Volume 2 contains papers dealing with polder construction, agricultural, socioeconomic, physical planning and environmental aspects; Vol...

Cumming, R.G.; Klineberg, R.J., 1994: Case-control study of risk factors for hip fractures in the elderly. The objective of this population-based case-control study was to identify risk factors for hip fracture among elderly women and men, particularly factors during young and middle adult life. The study base comprised people aged 65 years and over li...