geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Antithrombin III substitution in dialysis-dependent renal insufficiency


, : Antithrombin III substitution in dialysis-dependent renal insufficiency. Deutsche Medizinische Wochenschrift 107(48): 1847-1850

Haemodialysis had become impossible or possible only using high doses of heparin in 20 patients with dialysis-dependent renal insufficiency due to lowering of antithrombin III (AT III). In order to assess the value of AT III substitution for effective heparin treatment and concomitant diminution of the danger of haemorrhage AT III substitution was done in these patients. Six patients. Six patients with acute renal failure and disseminated intravascular coagulation were able to undergo dialysis using only 750-1000 IU heparin/h after normalisation of AT III without complications. In 3 patients thrombosing of the extracorporeal system had occurred despite increasing doses of heparin; only after 1500 U AT III subsequent haemodialysis could be performed without thromboses. Dialysis was performed with continuous substitution of the AT III-heparin-complex in 6 patients prone to haemorrhage. 250-500 U of AT III-heparin-complex were sufficient and proved as safe and well manageable possibility of minimal anticoagulation. In 5 patients repeated thrombosing of the haemofilter per day had occurred during continuous arteriovenous haemofiltration. After AT III administration haemofilters could be left in situ for 18-46 hours.

US$19.90

PMID: 7140568

DOI: 10.1055/s-2008-1070219


Other references

Liu, J.; Shu, Y.; Zhang, Q.; Liu, B.; Xia, J.; Qiu, M.; Miao, H.; Li, M.; Zhu, R., 2014: Dihydromyricetin induces apoptosis and inhibits proliferation in hepatocellular carcinoma cells. Hepatocellular carcinoma (HCC) is a life-threatening disease that is known to exhibit a poor prognosis. Therefore, it is important to identify an effective drug therapy for the treatment of HCC. Dihydromyricetin (DHM) is a flavonoid compound, isol...

Jiang, Y.; Han, T.; Zhang, Z-Guang.; Li, M.; Qi, F-Xiang.; Zhang, Y.; Ji, Y-Lan., 2017: Potential role of thymosin beta 4 in the treatment of nonalcoholic fatty liver disease. As a result of increased prevalence of obesity worldwide, non-alcoholic fatty liver disease (NAFLD) has become one of the most common causes of chronic liver disease. Although most NAFLD cases remain benign, some progress to end-stage liver diseas...

L.M.ra, V.; Abraldes, J.G.; Berzigotti, A.; Erice, E.; Flores-Arroyo, A.; García-Pagán, J.Carlos.; Bosch, J., 2010: Right atrial pressure is not adequate to calculate portal pressure gradient in cirrhosis: a clinical-hemodynamic correlation study. Hepatic venous pressure gradient (HVPG), the difference between wedge and free hepatic venous pressure, is the preferred method for estimating portal pressure. However, it has been suggested that hepatic atrial pressure gradient (HAPG)--the gradie...

Sato, K.; Shoji, T.S., 1957: Pathogenicity of Rhizoctonia solani Kuhn isolated from graminaceous weeds in forestry nurseries. Isolates of Rhizoctonia solani from grasses, Pinus densiftora, and Robinia pseudoacacia caused severe damping-off of pine seedlings in inoculation experiments. The grass isolates were more virulent to Amorpha fruticosa, dent corn, and Setaria lute...

Cheung, C.Y.; Anseth, K.S., 2006: Synthesis of immunoisolation barriers that provide localized immunosuppression for encapsulated pancreatic islets. Pancreatic islet encapsulation into synthetic, passive material matrixes can provide protection for transplanted islets from destruction via cell-contacted mediated interactions with autoreactive immune cells for treatment of Type I diabetes melli...

Hasan, N.; Nester, E.W., 1978: Purification and properties of chorismate synthase from Bacillus subtilis. Chorismatic synthase was purified to apparent homogeneity from Bacillus subtilis. The enzyme required NADPH-dependent flavin reductase, Mg2+, NADPH, and flavin (FMN or FAD) for activity. The molecular weight of chorismate synthase was 24,000 as de...

Fujita, T.; Tsuda, T.; Nonaka, R.; Miyajima, T.; Tanaka, Y.; Kodama, M.; Izumi, T.; Shibata, A., 1992: A case of dilated cardiomyopathy with intractable heart failure treated with adjunctive therapy of pimobendan and denopamine. Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 81(7): 1108-1110

Boiko S.S.; Zherdev V.P., 1991: Peculiarities of the pharmacokinetics of a new psychotropic drug with nootropic action onk 10 in the offspring of alcoholized animals. There were found significant differences in the pharmacokinetics of a new psychotropic drug with nootropic action ONK-10 following a long-term administration to the offspring of the intact animals as compared with the pharmacokinetics after a sing...

Chintamani, B.M.; Subbarayappa, B.V., 1971: History of sciences in India: Pali sources. Indian Journal of History of Science 6: 103-112

Weisberg, R.; Wald, M., 1984: Confidentiality laws and state efforts to protect abused or neglected children: the need for statutory reform. Family Law Quarterly 38(2): 143-212