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Aqueous bile salt-lecithin-cholesterol systems: equilibrium aspects


, : Aqueous bile salt-lecithin-cholesterol systems: equilibrium aspects. Hepatology 4(5 Suppl): 151s-154s

Cholesterol is solubilized by bile salt and bile salt-lecithin micelles without appreciable alteration in preexisting micellar size or structure. In dilute (approximately 3 gm per dl) model bile, but not in concentrated (approximately 10 gm per dl) systems, supramicellar concentrations of cholesterol are also solubilized in "stable" microdispersions of small lecithin-cholesterol vesicles (approximately 200 to 400 A in radius). Under physical-chemical conditions of physiological importance, the micellar solubilities of cholesterol are influenced by the total lipid concentrations, lecithin-to-bile salt ratio and bile salt species. The hydrophilic-hydrophobic balance of the bile salt monomer also influences the number and composition of precipitate phases coexisting in equilibrium with saturated micelles. When diluted below the critical micellar concentration (more correctly, the intermicellar concentration) of the bile salt species, the systems no longer contain micelles, but cholesterol remains dispersed in unilamellar liposomes that form spontaneously from the mixed micellar concentrations of the biliary lipids.

US$29.90

PMID: 6479872


Other references

Bullock, T.H., 1977: Tonic functions of afferent systems: an evaluation of implied concepts. Annals of the New York Academy of Sciences 290: 35-42

Sevketoglu, E.; Yildizdas, D.; Horoz, O.Ozgur.; Kihtir, H.Serdar.; Kendirli, T.; Bayraktar, S.; Carcillo, J.A., 2015: Use of therapeutic plasma exchange in children with thrombocytopenia-associated multiple organ failure in the Turkish thrombocytopenia-associated multiple organ failure network. Thrombocytopenia-associated multiple organ failure can lead to high mortality in critically ill children, possibly related to consequences of thrombotic microangiopathy. Plasma exchange therapy may improve thrombotic microangiopathy. The purpose o...

Gomes, I.; Nora, D.B.; Becker, J.; Ehlers, Jão.Arthur.C.; Schwartz, I.V.D.; Giugliani, R.; Ashton-Prolla, P.; Jardim, L., 2003: Nerve conduction studies, electromyography and sympathetic skin response in Fabry's disease. We prospectively performed neurophysiologic studies in nine Fabry's Disease (FD) patients (8 male and 1 female) in order to describe the results of nerve conduction studies (NCS) and electromyography (EMG) and to verify whether the sympatheti...

Chaumeil, H.; Signorella, S.; L.D.ian, C., 2000: Suzuki cross-coupling reaction of sterically hindered aryl boronates with 3-iodo-4-methoxybenzoic acid methylester. The cross-coupling reaction of 3-iodo-4-methoxybenzoic acid methylester with sterically hindered arylboronic esters and especially 5,5-dimethyl-2-mesityl-1,3,2-dioxaborinane, is reported. The optimisation of the process in order to obtain biaryls...

Smith, I.; White, P.F.; Nathanson, M.; Gouldson, R., 1994: Propofol. An update on its clinical use. Anesthesiology 81(4): 1005-1043

Kelly, A.L., 1999: The influence of heat treatment of milk on proteolysis in Cheddar cheese during ripening. The effects of different heat treatments applied to milk (UHT and pasteurized milk were compared to raw milk) and the addition of 0.1 mM KIO3 before heating on proteolysis in milk, composition of Cheddar cheese made from the milk, and proteolysis...

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van der Linden, A.; Blust, R.; Cuypers, K.; Thoeye, C.; Bernaerts, F., 1987: An action spectrum for light-induced hatching of Artemia cysts. Unknown

Brown, AF., 1987: Anatomical variability and secondary sexual characteristics in Pomphorhynchus laevis (Muller, 1776) (Acanthocephala). A brief historical survey demonstrates the differences in opinion concerning the taxonomic status of species within the genus Pomphorhynchus. The anatomy of P. laevis from a single population in the River Severn, UK was found to be highly variable...

Nicolas, S., 1940: Forestry and forest resources in Haiti. Haiti's 300 sq. miles or so of fairly dense Pinus occidentalis constitute a forest resource of great potentiality. Re-afforestation of abandoned farm lands is urgently needed for soil and water conservation, and for protection from dry trade...