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Aucubin: potential antidote for alpha-amanitin poisoning

, : Aucubin: potential antidote for alpha-amanitin poisoning. Journal of Toxicology. Clinical Toxicology 22(1): 77-85

Aucubin, an iridoid glucoside isolated from Aucuba japonica (Cornaceae), exhibited significant protective activity against alpha-amanitin intoxication in mice. When a single dose of aucubin was administered intraperitoneally, a 50% survival rate was obtained even when the treatment was withheld for 12 hr after alpha-amanitin administration. A possible mechanism of protective activity is partly due to a competitive effect of aucubin on alpha-amanitin inhibition of liver RNA biosynthesis.


PMID: 6208374

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