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Autoantibodies in malignant lymphoma of the thyroid gland

, : Autoantibodies in malignant lymphoma of the thyroid gland. New England Journal of Medicine 276(7): 380-383

Six patients with malignant lymphoma of the thyroid gland were seen in the Tokyo University Hospital in the past 13 years. The clinical findings and laboratory data, with specific reference to antithyroid antibodies, are reviewed. Resection of the involved thyroid gland was carried out in all patients. Regional-lymph-node dissection was performed in 2 cases. In 4 cases postoperative irradiation was added. Tanned red-cell antibody was positive in 3 cases before and in 4 cases after operation. Antibody to microsome complement fixation was demonstrated in low titer in 2 cases and absent in 2 cases; the test was not done in 2 others. The mechanism of production and maintenance of antithyroid antibodies in malignant lymphoma of the thyroid gland is discussed.


PMID: 5334615

DOI: 10.1056/NEJM196702162760704

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