geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Biological effects of bone-seeking alpha emitters with respect to the risk of internal contamination in man


, : Biological effects of bone-seeking alpha emitters with respect to the risk of internal contamination in man. Czechoslovak Medicine 5(2): 80-89

Some results of long-term experiments performed in mice contaminated with 226Ra and 239Pu, especially the damage to the hemopoietic system and the incidence of osteosarcoma, are reported. Different degree of damage to the bone marrow hemopoiesis, depending on the arrangement of marrow cavities and the capability of stem cells to produce differentiated progeny are evaluated. This ability decreases with age and with duration of the contamination due to radionuclides. From the above aspects of radiation injury the ability of hemopoiesis to compensate the decreased production of differentiated peripheral cell forms is discussed. It is remarkable that myeloid leukemia occurred earlier and more frequently in 239Pu-contaminated animals than in controls. After the injection of plutonium-239, myeloid and lymphatic leukemias were diagnosed in most of the animals dying without osteosarcoma. These diseases represented a danger not lower than that of osteosarcoma which appeared in average later and the expected incidence of which was estimated to rise linearly with age. The findings are discussed from the aspect of their application in evaluating the risk resulting for man from the incorporated bone-seeking alpha emitters.

US$29.90

PMID: 6811232


Other references

Wheeler, W.I., 1931: A Clinical Address ON THE SIGNIFICANCE OF RECOIL FOLLOWING VISCERAL DECOMPRESSION. Canadian Medical Association Journal 24(1): 3-8

Anderson K.P.; Ershler P.R.; Lux R.L.; Karwande S.V.; Gay W.A.; Urie P.M.; Runnels D.E.; Pace N.L.; Mason J.W., 1989: Nonuniform electrical activation in idiopathic dilated cardiomyopathy. Circulation 80(4 SUPPL 2): II431

Ohler, F.M.J., 2003: Impact of leasehold forestry on marginal mountain farms in Nepal. This paper presents a cohesive model for causal linkages from the leasehold forestry project intervention to its impact on marginal mountain farms of Nepal. Data collected from annual household surveys (1994-99), group and site information (2000),...

Connelly, F.C., 1958: An apparatus for the accurate control of x-ray exposure times. British Journal of Radiology 31(369): 510-513

Koh, J.L.; Zwahlen, B.A.; Altchek, D.W.; Zimmerman, T.A., 2017: Arthroscopic treatment successfully treats posterior elbow impingement in an athletic population. Posterior elbow impingement can cause disabling pain and limited motion during activities involving elbow extension. Less understood is whether arthroscopic treatment, compared to open surgery, can result in effective management of pain, loss of r...

Reuter, S.; Charlet, J.; Juncker, T.; Teiten, M-Hélène.; Dicato, M.; Diederich, M., 2009: Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells. Curcumin, a natural product isolated from the plant Curcuma longa, has a diverse range of molecular targets that influence numerous biochemical and molecular cascades. Curcumin has been shown to inhibit nuclear factor kappaB (NF-kappaB) activation...

White, Paula A., 2005: Maternal rank is not correlated with cub survival in the spotted hyena, Crocuta crocuta. Reproductive success in female spotted hyenas, Crocuta crocuta, is positively correlated with social rank. High-ranking females are known to produce more offspring, but the effects of maternal rank on early cub survivorship have not been investiga...

Anonymous, 1982: Cameroon: agriculture in the 5th plan 1982-1986. Part I. Crops. In this first part, dealing with crops, the positive results obtained in the preceding 4th Plan are briefly reviewed. In the 5th plan efforts on agricultural and rural development, in order to reduce the rural exodus, will be increased. The creati...

Geiger, H.L.; Holyoak, A.R., 1996: Preference of adults of the dorid nudibranchs Archidoris montereyensis , Diaulula sandiegensis , and Triopha catalinae for shaded over lighted conditions. Veliger 39(1): 95-97

Usdin, K., 1998: NGG-triplet repeats form similar intrastrand structures: implications for the triplet expansion diseases. Tandem repeats of certain trinucleotides show extensive intergenerational instability in humans that is associated with a class of genetic disorders known as the Triplet Expansion Diseases. This instability is thought to be a consequence of the fo...