+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Biopsy and post-mortem findings in a patient receiving cerebellar stimulation for epilepsy

, : Biopsy and post-mortem findings in a patient receiving cerebellar stimulation for epilepsy. Journal of Neurology, Neurosurgery, and Psychiatry 46(3): 266-273

Cerebellar stimulating equipment was implanted in a 24-year-old male with severe epilepsy. He received continuous alternating stimulation for at least two months, intermittent bilateral stimulation on demand for at least two months and numerous short bursts of stimulation during preliminary testing and calibration of the apparatus. The patient died during a prolonged grand mal seizure 16 months after implantation and this paper reports the findings at necropsy. A special study was made of the degree of tissue damage in the cerebellar hemispheres resulting from implantation of the electrodes and subsequent cerebellar stimulation. There was deep grooving of the upper aspect of the cerebellum under the electrodes but only a minor degree of neuronal loss and gliosis was observed in the underlying cortex. Purkinje cell populations in the cerebellum at necropsy were similar to those in a biopsy specimen taken 16 months previously during implantation. The electrodes were covered with a thick layer of fibrous tissue but they were not adherent to the cerebellar surface. Thus, the main significant findings in the present case were the very slight structural damage to the cerebellum in contact with the electrodes and the intense fibrosis around the electrodes themselves. These features are discussed in relation to the efficacy of long-term cerebellar stimulation.


PMID: 6405013

Other references

Schumann, R.R.; Nakarai, T.; Gruss, H.J.; Brach, M.A.; von Arnim, U.; Kirschning, C.; Karawajew, L.; Ludwig, W.D.; Renauld, J.C.; Ritz, J.; Herrmann, F., 1996: Transcript synthesis and surface expression of the interleukin-2 receptor (alpha-, beta-, and gamma-chain) by normal and malignant myeloid cells. Expression of the interleukin-2 receptor alpha- (IL-2R-alpha), IL-2R-beta-, and the recently identified IL-2R-gamma-chain was examined on a wide range of cells of myeloid origin including neutrophils, monocytes, normal bone marrow-derived myeloid...

Mott, R.J.; Farley-Gill, L.D., 1978: A late quaternary pollen profile from woodstock ontario canada. Maplehurst Lake, situated in a former interlobate zone that was deglaciated relatively early compared to adjacent areas of southern Ontario [Canada] provides one of the more complete pollen records for the region. Radiocarbon dates [5] allow deter...

Askanas V.; Cave S.; Martinuzzi A.; Engel W.K., 1986: Glucocorticoids increase number of acetylcholine receptors and acetylcholine receptor aggregates in human muscle cultured in serum free hormonally chemically defined medium. Neurology 36(4 SUPPL 1): 241

Luboshitzky, R.; Dgani, Y.; Atar, S.; Qupty, G.; Rakover, Y.; Tamir, A.; Flatau, E., 1994: Thyroid dysfunction and goiter among immigrants from Ethiopia. 1131 immigrants from Gonder, Ethiopia were surveyed a year after arrival in Israel. The overall prevalence of goiter was 46.1%; the lowest rates (6.7%) were in infants (aged 1-2 years) and the peak prevalence in males was 56.7% (in those aged 12-1...

Timmins, N., 2013: Response on reviews of 'Never again?'. Health Economics, Policy, and Law 8(2): 265-268

Kulkarni, K.; Karssiens, T.; Kumar, V.; Pandit, H., 2016: Obesity and osteoarthritis. This paper provides an up-to-date review of obesity and lower limb osteoarthritis (OA). OA is a major global cause of disability, with the knee being the most frequently affected joint. There is a proven association between obesity and knee OA, an...

Ovczinnikova, S.V., 2006: The system of the subtribe Echinosperminae (Tribe Eritrichieae, Boraginaceae). The subtribe Echinosperminae is distinguished within the tribe Eritrichieae, Boraginaceae. The system of the subtribe Echinosperminae is given: it includes two genera, Lappula and Lepechiniella. The genus Lappula includes 70 species, 8 sections an...

Goia, I.; Chirtoc, G.; Mazilu, A.; Florea, M., 1956: Role of the central nervous system in rheumatic disease. Probleme de Reumatologie 4: 45-53

Sinskey, Aj, 1976: New developments in intermediate moisture foods: humectants. Intermediate Moisture Foods: 60-280

Shi, Q.; Stell, W.K., 2014: Die Fledermaus: regarding optokinetic contrast sensitivity and light-adaptation, chicks are mice with wings. Through adaptation, animals can function visually under an extremely broad range of light intensities. Light adaptation starts in the retina, through shifts in photoreceptor sensitivity and kinetics plus modulation of visual processing in retinal...