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Bladder cancer induction by aromatic amines: role of N-hydroxy metabolites

, : Bladder cancer induction by aromatic amines: role of N-hydroxy metabolites. Science 167(3920): 992-993

Repeated installation of N-hydroxy-2 naphthylamine into dog bladders produced tumors of this organ. There is a correlation of degree of carcinogenicity of 1-naphthylamine, 2-naphthylamine, and 4-aminobiphenyl with both methemoglobin production in the blood and concentration of N-oxidation products in the urine. Thus, N-hydroxylation appears to be the key to bladder cancer production by aromatic amines.


PMID: 5411180

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