+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cell-surface interactions: differential inhibition by proflavine of embryonic cell aggregation and production of specific cell-aggregating factor

, : Cell-surface interactions: differential inhibition by proflavine of embryonic cell aggregation and production of specific cell-aggregating factor. Proceedings of the National Academy of Sciences of the United States of America 70(11): 3111-3114

Cell recognition and morphogenetic aggregation of embryonic cells into tissues are mediated by specific macromolecules in the cell surface (cell-aggregating factors). A factor specific for embryonic neural retina cells was demonstrated; its synthesis is required for histotypic reaggregation of retina cell suspensions. We show that proflavine (3,6-diaminoacridine) preferentially and reversibly suppresses production of the cell-aggregating factor and thereby inhibits normal cell reaggregation. If such proflavine-treated retina cells are exogenously supplied with the retina-specific factor, they reaggregate. The selectivity of these effects supports the postulated significance of specific cell-surface components in cell association into tissues; the results indicate that proflavine may be a useful molecular probe for studying formation of specific cell-surface components and their role in various cell interactions.


PMID: 4522293

Other references

Millar, Jocelyn, G., 2006: Editors' preface (papers by J.R. Miller, L.J. Gut, F.M. de Lame, and L.L. Stelinski). Journal of Chemical Ecology 32(10): 2085-2087

Tariq, Z.; Ghose, A.; Sofi, A.; Mohamed, I.; Harmon, D., 2012: Metastatic renal extraskeletal Ewing sarcoma in complete remission for the last 8 years. Primary renal extraskeletal Ewing sarcoma (EES) is rare but well known to be aggressive, less responsive to the treatment, and has early predilection for metastases. Metastases at the time of diagnosis to the lungs or bones are associated with poo...

Chacron, M.J.; Lindner, B.; Longtin, Aé., 2004: Noise shaping by interval correlations increases information transfer. The influence of intrinsic firing interspike interval correlations on the noise spectrum and information transfer is studied. This is done through the comparison of two simple firing models, one of which is a renewal process while the other displa...

Roehr, B., 2012: Researchers find no link between XMRV and chronic fatigue syndrome. Bmj 345: E6331-E6331

de la Rosa, G.; Longo, N.; Rodríguez-Fernández, J.L.; Puig-Kroger, A.; Pineda, A.; Corbí, A.L.; Sánchez-Mateos, P., 2003: Migration of human blood dendritic cells across endothelial cell monolayers: adhesion molecules and chemokines involved in subset-specific transmigration. Distinct subsets of dendritic cells (DCs) are present in blood, probably "en route" to different tissues. We have investigated the chemokines and adhesion molecules involved in the migration of myeloid (CD11c(+)) and plasmacytoid (CD123(...

Saleh, A., 1979: Romanias sunflowerseed production declines. Foreign agriculture 17(6): 11

Monforte, A.Rita.; Jacobson, D.; Silva Ferreira, A.C., 2015: Chemiomics: network reconstruction and kinetics of port wine aging. Network reconstruction (NR) has proven to be useful in the detection and visualization of relationships among the compounds present in a Port wine aging data set. This view of the data provides a considerable amount of information with which to un...

Enami J.; Arai O.; Saito N.; Yamaoka S., 1990: Growth of nerve cells cultured in alginate coated collagen gel fibers. Japanese Journal of Physiology 40(SUPPL): S20

Balabanoff, V.A.; Usunov, P., 1970: The vitality of saprophytic and pathogenic dermatophytes in natural biocenosis of the soil. Mykosen 13(3): 145-154

Medler, A., 1956: Orbital and middle and posterior cranial fossa injuries caused by wedge-shaped piece of wood with surprisingly insignificant complications. Klinische Monatsblatter für Augenheilkunde und für Augenarztliche Fortbildung 129(4): 543-546