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Clinical pharmacology of prazosin in hypertensive patients with chronic renal failure


, : Clinical pharmacology of prazosin in hypertensive patients with chronic renal failure. Journal of Cardiovascular Pharmacology 3(1): 151-160

The clinical pharmacology of prazosin was studied in 10 hypertensive patients with chronic renal failure (group I) and in 9 hypertensive patients with normal renal function (group II). Prazosin, 2 mg, was given orally and blood samples were drawn at intervals for spectrofluorimetric assay. Blood pressure and heart rate were obtained at the same time. In the renal failure group, prazosin induced a significant decrease in systolic and diastolic blood pressures (-19 and -23%, respectively) at 90 min after intake, and these alterations were more rapid and marked than in the normal renal function group. Peak plasma concentration (Cmax) was higher (33.5 +/- 3.7 vs. 20.04 +/- 1.7 micrograms/liter, p < 0.01) and occurred earlier (1.3 +/- 0.2 vs. 2.7 +/- 0.3 hr, p < 0.005) in group I than in group II. The area under the plasma concentration-time curve (AUC0 infinity) was increased in the renal failure group (206.1 +/- 31.1 vs. 112.4 +/- 9.4 micrograms/hr/liter, p < 0.01). Apparent plasma elimination half-life (t 1/2) was not significantly different in the two groups (3.6 +/- 0.4 vs. 2.9 +/- 0.3 hr. ns). The mean blood pressure change (delta MBP%) was significantly correlated with the plasma level of prazosin in the renal failure group (n = 97, r = 0.489, p < 0.001) but not in patients with normal renal function (n = 74, r = 0.297, ns). The hypotensive action of prazosin is greater in patients with chronic renal failure, and the bioavailability or distribution of the drug is altered. Therefore, prazosin dosages should be modified in patients with impaired renal function.

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PMID: 6160344


Other references

Chiang, T.S.; Leaders, E., 1968: Dissociation between the initial negative and the secondary positive chronotropic and inotropic effects of nicotine in rat atria. Archives Internationales de Pharmacodynamie et de Therapie 172(2): 347-355

Cunningham J.; Sayyed G.A.; Srijaranai S.; Debauge Y., 1992: Adsorption of model pollutants on titanium dioxide particles in relation to photoremediation of contaminated water. Abstracts of Papers American Chemical Society 203(1-3): ENVR30

Lappin, M.R., 1996: Feline toxoplasmosis: interpretation of diagnostic test results. Based on seroprevalence studies, approximately 30% of the cats in the United States have been infected by T. gondii. Cats are the only species that pass the environmentally resistant oocyst in feces. Sporulated oocysts are infectious to humans and...

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Clift, C., 1977: Cold damage to cycads and palms at Fairchild Tropical Garden resulting from the January 1977 freeze. Proceedings of the annual meeting: 0 96-98

Wang, X.; Sha, Y.; Ge, Z.; Wang, W.; Li, R., 2011: Fragmentation patterns of novel dithiocarbamate derivatives with pharmaceutical activity under electrospray ionization tandem mass spectrometry conditions. The fragmentation patterns of a novel series of dithiocarbamate derivatives with pharmaceutical activity were investigated by positive ion electrospray ionization mass spectrometry in conjunction with tandem mass spectrometry (ESI-MS(n)). In the g...

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Urbach F., 1989: The biological effects of increased uv radiation an update introduction. Photochemistry & Photobiology 50(4): 439-442

Whittaker, J.H.; Robertson, A.P.; Kimber, M.J.; Day, T.A.; Carlson, S.A., 2017: Intestinal Enterobacteriaceae that Protect Nematodes from the Effects of Benzimidazoles. The objective of this study was to investigate an interaction between nematodes and gut Enterobacteriaceae that use benzimidazoles as a carbon source. By addressing this objective, we identified an anthelmintic resistance-like mechanism for gastro...

Anonymous, 2005: Champion trees: a selection of Ireland's great trees. Lists are given of champion and remarkable trees for the whole island of Ireland, and by county in both the Republic of Ireland and Northern Ireland.