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Complement fixation by IgM and IgG autoantibodies on cultured human glial cells

, : Complement fixation by IgM and IgG autoantibodies on cultured human glial cells. Journal of Neurosurgery 55(1): 19-26

The humoral immune response to autologous gliomas has been investigated in 16 patients using immune adherence and anti-C3 immunofluorescence assays of serum samples. Significant antiglioma antibody activity was detected in 56% of these sera. Fractionation experiments demonstrated that IgM class antibodies were more effective that IgG in their ability to fix complement on cultured glioma cell membranes. In addition, autologous IgG was shown to inhibit IgM complement-fixing activity in some experiments. "Capping" of immune complexes on the glioma cell surface is also described.


PMID: 7017080

DOI: 10.3171/jns.1981.55.1.0019

Other references

Mcdowell, G.; Keevil, B., 2001: Use of anti-platelet agents to prevent in vitro activation during sampling for thrombospondin. Clinical Science (London) 101(2): 8P, August

Rich, M.W.; Radwany, S.M., 1994: Respiratory dyskinesia. An underrecognized phenomenon. Chest 105(6): 1826-1832

Clark, H.L., 1915: The Comatulids of Torres Strait: with special reference to their habits and reactions. Washington Ders from Dept: 67-125

Ding, Z-yi., 2004: Metallothionein and prevention and treatment of environmental risk factors for health. Zhonghua Er Ke Za Zhi 41(7): 510-514

Singh, V.; Jaiswal, A.; Porter, J.D.H.; Ogden, J.A.; Sarin, R.; Sharma, P.P.; Arora, V.K.; Jain, R.C., 2002: TB control, poverty, and vulnerability in Delhi, India. The Revised National Tuberculosis Control Programme (RNTCP), based on the World Health Organization's DOTS strategy,* was introduced in India in the mid-1990s. This paper reports the findings from operational research studies in two pilot sit...

Kim, H.Rim.; Leavis, P.C.; Graceffa, P.; Gallant, C.; Morgan, K.G., 2010: A new method for direct detection of the sites of actin polymerization in intact cells and its application to differentiated vascular smooth muscle. Here we report and validate a new method, suitable broadly, for use in differentiated cells and tissues, for the direct visualization of actin polymerization under physiological conditions. We have designed and tested different versions of fluores...

Mastin, Mark, 2010: Suspended sediment transport in the Skagit River delta; recent measurements. U. S. Geological Survey: 17-18

Nichols, J.T., 1929: The fishes of Porto Rico and the Virgin Islands. Branchiostomidae and Sciaenidae. Scientific Survey of Porto Rico and the Virgin Islands, 10: 180-181

Lazarus D.B.; Hays J.D.; Prothero D.R., 1982: Evolution in radiolaria implications for study of tempo and mode using micro fossil data. Journal of Paleontology 56(2 SUPPL): 16

Suhadev, M.; Nyamathi, A.M.; Swaminathan, S.; Venkatesan, P.; Raja Sakthivel, M.; Shenbagavalli, R.; Suresh, A.; Fahey, J.L., 2007: A pilot study on willingness to participate in future preventive HIV vaccine trials. In India, phase-I human clinical trials for a preventive HIV vaccine are being conducted at Pune and Chennai Centres. In order to find out the willingness of populations at risk to participate in future preventive HIV vaccine trials (HIVVTs) and t...