+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Decreased myocardial function and myosin ATPase in hearts from diabetic rats

, : Decreased myocardial function and myosin ATPase in hearts from diabetic rats. American Journal of Physiology 244(4): H586-H591

The effect of diabetes on cardiac function was determined in isolated rat hearts. Diabetes was induced by injection of alloxan (doses ranged from 37.5 to 60 mg/kg body wt), and the heart were removed and perfused in the working heart preparation. Doses of alloxan ranging from 37.5 to 42 mg/kg did not consistently alter cardiac function even though serum glucose was elevated and serum thyroid hormones were reduced. Injection of 45 mg/kg of alloxan caused a large increase in serum glucose and a larger decrease in thyroid hormones. In this case, ventricular function was more consistently depressed after 1-2 wk. Function was not altered 48 h after injection of 60 mg kg of alloxan. However, when animals were given 60 mg/kg of alloxan and then maintained on insulin for 7 days, depressed cardiac function developed within 4 days after the insulin treatment was stopped. The decline in function involved a decrease in heart rate peak systolic pressure, and left ventricular +dP/dt. It was associated with greatly reduced serum thyroid hormones (both T3 and T4) and lower ventricular Ca2+-activated myosin ATPase activity. Fasting of rats for 4 days also resulted in decreased serum T3 and T4, depressed cardiac function (although heart rate was unchanged), and lower Ca2+-activated myosin ATPase activity.


PMID: 6220613

Other references

Griffith, J.M.; Coffey, M.D.; Grant, B.R., 1993: Phosphonate inhibition as a function of phosphate concentration in isolates of Phytophthora palmivora. Three isolates of Phytophthora palmivora showing differing sensitivities to phosphonate were grown in the presence of a uniform concentration of the anion (1 mM), together with concentrations of phosphate which varied from zero to 3 mM. The phosph...

Bywaters, E.G.; Hamilton, E.B.; Williams, R., 1971: The spine in idiopathic haemochromatosis. Annals of the Rheumatic Diseases 30(5): 453-465

Blankenship, K.L.; Wegener, D.T.; Murray, R.A., 2016: Values, inter-attitudinal structure, and attitude change: value accessibility can increase a related attitude's resistance to change. Accessibility is one of the most basic structural properties of an attitude and an important factor to consider in attitude strength. Despite its importance, relatively little work has examined the role of attitude accessibility in an inter-attitu...

Woodbury, M., A.; Fillenbaum, G., G., 1996: Psychometric characteristics of the Mini-Mental State Examination in patients with Alzheimer's disease- A grade of membership analysis of CERAD data: Part II. In order to determine whether the Mini-Mental State Examination (MMSE) assesses multiple areas of cognitive functioning, a grade of membership analysis, carried out initially on data from a representative sample of community residents (see Part I)...

Lawrie, R.A.; Bendall, J.R.; Scopes, R.K.; Penny, I.; Voyle, C.A., 1966: Biochemistry and physiology of meat. The pale, watery condition of meat frequently obtained from certain breeds of pig was shown to be due to particularly rapid acidification of muscles by lactic acid under conditions of nervous excitement. Improved factory conditions before slaughte...

Isachsen C.E.; Bowring S.A., 1993: U-Pb geochronology of the Yellowknife volcanic belt; 340 Ma of crustal evolution. Program with Abstracts - Geological Association of Canada(Mineralogical Association of Canada(Canadian Geophysical Union, Joint Annual Meeting 1993: 47

Handy, T.C.; Shroff, N.M.; Ketay, S.B.; Grafton, S.T.; Gazzaniga, M.S., 2002: Grabbable objects grab attention. It has been proposed that whether or not a visual object affords action can have a modulatory effect on whether or not attention is oriented to that object (Ward, 1999). To test this prediction we developed a novel paradigm for use with ERPs and f...

Geber, C.; Birklein, F., 2016: "Symptom vs sensory profiling"-taking one step after the other. Pain 157(11): 2617-2619

Ottaviani, Sébastien.; Richette, P.; Allard, A.; Ora, Jérémy.; Bardin, T., 2012: Ultrasonography in gout: a case-control study. To determine the sensitivity and specificity of ultrasonography for gout, and to investigate the relationship with severity of gout. In this case-control study, we prospectively enrolled 53 patients with crystal-proven gout and 50 controls. Ultras...

Mohamed Abdelzaher, Jun Nishijima, Hakim Saibi, Gad El-Qady…, 2012: A Coastal Aquifer Study Using Magnetotelluric and Gravity Methods in Abo Zenema, Egypt. Magnetotelluric (MT) soundings and gravity methods were employed to study the deep freshwater aquifer in the area north of Abo Zenema city on the eastern side of the Gulf of Suez, Egypt. Seven MT sites and 48 gravity stations were surveyed along n...