geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Delayed neurotoxicity - do trichlorphon and/or dichlorvos cause delayed neuropathy in man or in test animals?


, : Delayed neurotoxicity - do trichlorphon and/or dichlorvos cause delayed neuropathy in man or in test animals?. Acta Pharmacologica et Toxicologica 49 Suppl 5: 87-98

Many, but not all, reports of delayed neuropathy associated with acute poisoning by trichlorphon refer to cases in U.S.S.R. Adulteration of technical trichlorphon with the ethyl analogue would greatly increase the neurotoxic hazard but analysis of a few samples has not revealed such impurities. Simultaneous ingestion of alcohol does not appear to increase neuropathic hazard. In hens double doses of trichlorphon each exceeding unprotected LD50 can produce moderate neuropathy associated with appropriately high inhibitions of neurotoxic esterase. Similar results are obtained with 2 doses of 10 x LD50 of dichlorvos. In vitro the inhibitory power of dichlorvos against neurotoxic esterase of hen brain is 0.02 x the power against acetylcholinesterase. This ratio correlates reasonably with the ratio of LD50/neuropathic dose. The factor for human brain enzymes is 0.06 suggesting that man is more susceptible to neuropathic effects of near-lethal doses of circulating dichlorvos. It is concluded that the only neuropathic hazard to man from good quality trichlorphon arises from rapid ingestion of massive doses. To obtain critical levels of inhibition of neurotoxic esterase and to cause neuropathy in man by repeated doses would require each dose to be severely toxic. Dichlorvos ingested in large doses is likely to kill rather than to cause neuropathy.

US$29.90

PMID: 7344417


Other references

Tiwari S.P.; Bhatnagar P.S., 1991: Pod shattering as related to other agronomic attributes in soybean. Correlation and path analysis of pod shattering in relation to seven other agronomic characters was carried out in 21 cultivars of soybean. Pod shattering showed a significant negative correlation (r = 0.51) with 100 seed-weight. Path analysis rev...

Janka, H.U., 1990: Epidemiology and risk factors of macrovascular disease in diabetes mellitus. Cardiovascular diseases are the major cause of morbidity and mortality in the diabetic patient. The acceleration of atherogenesis occurs in all types of diabetes and culminates in such fatal complications as myocardial infarction, stroke and gangr...

Anonymous, 1979: Work of the journal, Problemy tuberkuleza, in 1979. Problemy Tuberkuleza: 3-5

Bezemer, R.; Klijn, E.; Khalilzada, M.; Lima, A.; Heger, M.; van Bommel, J.; Ince, C., 2010: Validation of near-infrared laser speckle imaging for assessing microvascular (re)perfusion. The present study was conducted to compare laser speckle imaging (LSI) with sidestream dark field (SDF) imaging (i.e., capillary microscopy) so as to validate the use of LSI for assessing microvascular (re)perfusion. For this purpose, LSI and SDF...

Dadant, R., 1950: On a new disease of Coffea robusta in New Caledonia. Robusta coffee in New Caledonia is affected by a fungus disease which causes the leaves to turn yellow, hang down, dry uniformly, and fall off after 7 to 14 days. The whole tree dies. As soon as the first outward symptoms appear the wood of a cons...

Hu, W.; Luo, Q.; Wu, K.; Li, X.; Wang, F.; Chen, Y.; Ma, X.; Wang, J.; Liu, J.; Xiong, S.; Sadler, P.J., 2011: The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Cisplatin, cis-[Pt(Cl(2)(NH(3))(2)], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.

Nishijima, K.; Ng, Y-Shan.; Zhong, L.; Bradley, J.; Schubert, W.; Jo, N.; Akita, J.; Samuelsson, S.J.; Robinson, G.S.; Adamis, A.P.; Shima, D.T., 2007: Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Vascular endothelial growth factor-A (VEGF-A) has recently been recognized as an important neuroprotectant in the central nervous system. Given its position as an anti-angiogenic target in the treatment of human diseases, understanding the extent...

Mitchell, B.M.; Dorrance, A.M.; Mack, E.A.; Webb, R.Clinton., 2003: Glucocorticoids decrease GTP cyclohydrolase and tetrahydrobiopterin-dependent vasorelaxation through glucocorticoid receptors. Excess glucocorticoids result in decreased aortic dilation and expression of guanosine triphosphate (GTP) cyclohydrolase 1 (GTPCH1) messenger RNA (mRNA), the rate-limiting enzyme in the production of the nitric oxide synthase (NOS) cofactor tetrah...

Ware, D.A., 1980: Pathogenicity of Campylobacter fetus subsp. venerealis in causing infertility in cattle. C. fetus ssp. venerealis rapidly lowered the dissolved O2 tension of its medium on addition of components of uterine fluid. This organism may cause infertility in cows by restricting the supply of O2 available to the preimplantation embryo.

Prochownik, E.V., 2004: c-Myc as a therapeutic target in cancer. c-Myc is frequently deregulated in human cancers. The c-Myc oncoprotein is a transcription factor, with many of its target genes encoding proteins that initiate and maintain the transformed state. c-Myc is also part of a dynamic network whose memb...