+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Detection of severity of coronary artery disease by the ST segment/heart rate relationship in patients on beta-blocker therapy

, : Detection of severity of coronary artery disease by the ST segment/heart rate relationship in patients on beta-blocker therapy. Cardiovascular Research 16(9): 508-515

Many patients presenting with anginal pain are on beta-blocker therapy and it has been suggested that noninvasive exercise tests for coronary artery disease are adversely affected by such therapy. Recently a new exercise test has been introduced claiming the ability accurately to detect the presence and severity of coronary heart disease in patients with anginal pain; the claim was based on results obtained in patients not undergoing beta-blocker therapy. Therefore using this test, the maximal rate of progression of ST segment depression relative to increases in heart rate during exercise (maximal ST/HR slope) as an index of the severity of myocardial ischaemia, 60 patients on beta-blocker therapy were studied and the results compared with results of coronary arteriography independently obtained. There was a complete agreement, without false results, between the maximal ST/HR slope and the number of significantly diseased coronary arteries. In 21 of these 60 patients the maximal ST/HR slopes obtained before and after beta-blockade were compared; the maximal ST/HR slopes after beta-blockade were not different from those before. It is concluded, that the maximal SR/HR slope can be used reliably to detect the pressure and the severity of coronary heart disease in patients with angina pectoris who are already on beta-blocker therapy.


PMID: 6293709

Other references

Buikin, A.I.; Korochantseva, E.V.; Hopp, J.; Trieloff, M.; Kogarko, L.N., 2008: Super 40 Ar-39 Ar dating of volcanic rocks from Fernando de Noronha hot spot. Geochimica et Cosmochimica Acta 72.12S: A119

Sahiner, B.; Chan, H.P.; Petrick, N.; Wagner, R.F.; Hadjiiski, L., 2000: Feature selection and classifier performance in computer-aided diagnosis: the effect of finite sample size. In computer-aided diagnosis (CAD), a frequently used approach for distinguishing normal and abnormal cases is first to extract potentially useful features for the classification task. Effective features are then selected from this entire pool of a...

Baumann, H., 1970: District medical orientation on Salmonella problems. Schweizerische Rundschau für Medizin Praxis 59(40): 1392-1394

San Roman, C.J., 1961: Causal venographic diagnosis in the varicose and postphlebitic leg. La Semana Medica 118: 1121-1128

Ishida, Juro, 1943: Non-precipitable nitrogen in frog skin with special reference to purine bases. Nitrogen substances of the dorsal and ventral skin of Rana nigromaculata were compared. Contents of total non-precipitable N, ammonia, amino N, total purine N, uric acid, guanine, total oxypurine and adenine were estimated. Total purine bases were...

Pearson H.E.; Stoffler D.J., 1991: Degeneration of medium sized retinal ganglion cells in response to loss of postsynaptic neurons in the dorsal lateral geniculate nucleus of the adult cat. Society for Neuroscience Abstracts 17(1-2): 627

Labarca-Acosta, Mía.; Reyna-Villasmil, E.; Aragón-Charris, J.; Santos-Bolívar, J., 2013: Pancreatic adenocarcinoma during pregnancy. Cirugia Espanola 93(7): 479-481

Bolt Bruce A., 1989: Memorial essay; Sir Harold Jeffreys (1891-1989). Bulletin of the Seismological Society of America 79(6): 2006-2011

Stein, R.S.; Kozin, F.; Rothwell, D., 1977: Chronic lymphocytic leukemia well differentiated lymphocytic lymphoma with mono clonal immuno globulin a immuno globulin a production by circulating lymphocytes. A patient is described in whom morphologic features of well-differentiated lymphocytic lymphoma (WDL) or chronic lymphocytic leukemia (CLL) and immunologic features of multiple myeloma were present. Studies of isolated peripheral blood lymphocytes...

Dunshee, B.R., E.Al., 1949: The isolation and properties of Antimycin A. Antimycin A is a highly potent, fungicidal antibiotic isolated from cultures of a Streptomyces species. It was tested against Colletotrichum and Stemphylium.