geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dianhydrogalactitol and cisplatin in combination for advanced cancer of the uterine cervix


, : Dianhydrogalactitol and cisplatin in combination for advanced cancer of the uterine cervix. Cancer Treatment Reports 66(10): 1809-1812

Eighteen evaluable patients with squamous cancer of the uterine cervix recurrent after radiation therapy or with distant metastases were treated with dianhydrogalactitol (150 mg/m2) and cisplatin (DDP) (50 mg/m2), both given iv every 3 weeks. Only 39% of the patients responded, a result no better than that previously reported for DDP alone and only one-half as good as that previously reported by our group for a combination of this drug with mitomycin, vincristine, and bleomycin. Responses lasted a median of only 5 months. Hematologic toxicity was life-threatening in 22% of the patients and was severe in all but 11% of the remaining patients. We conclude that the addition of substantial and toxic doses of dianhydrogalactitol to DDP failed to substantially enhance the rate, quality, or duration of response compared to DDP alone.

US$29.90

PMID: 6889913


Other references

Baratii, S., 1974: Irrigation and ecological problems in the area delimite by Sesia, Ticino and Po rivers. Riso 23 (1) 59-70

Heyworth, F., 1967: B663 in treatment of atypical tuberculous disease. Medical Journal of Australia 1(3): 106-107

Matthias Langensiepen; Moritz Kupisch; Mark T. van Wijk; Frank Ewert, 2012: Analyzing transient closed chamber effects on canopy gas exchange for optimizing flux calculation timing. Transient type canopy chambers are still the only currently available practical solution for rapid screening of gas-exchange in agricultural fields. The technique has been criticized for its effect on canopy microclimate during measurement which a...

Li, Y.; Li, S.; Chen, G., 2002: The relationship between HCY-2 gene and congenital heart teratogenesis in early chick embryos. To explore the relationship between novel gene (HCY-2), homocysteine and congenital heart defects, and to study their biological mechanisms. The teratogenic test of chick embryos which were treated with D.L-homocysteine (0.16 micromol/embryo) was...

Sugai T.; Kakeya H.; Ohta H.; Morooka M.; Ohba S., 1989: A synthesis of levo deoxypodocarpic acid methyl ester via an enzymatic enantioselective hydrolysis of the key intermediate enol ester. (1R,4aR,10aS)-(-)-1-Methoxycarbonyl-1,4a-dimethyl-1,2,3,4,4a,9,10, 10a-octahydrophenanthrene (deoxypodocarpic acid methyl ester 1), a useful intermediate for the synthesis of various diterpenes, was synthesized from (R)-(+)-6-ethoxycarbonyl-2,6-di...

Rose, L.F., 2014: From the editor: minimizing risk. Compendium of Continuing Education in Dentistry 34(9): 650-650

Hyman, M.R.; Arp, D.J., 1991: Kinetic analysis of the interaction of nitric oxide with the membrane-associated, nickel and iron-sulfur-containing hydrogenase from Azotobacter vinelandii. The effects of nitric oxide (NO) on the membrane-associated form of the nickel and iron-sulfur-containing hydrogenase from Azotobacter vinelandii have been investigated. In the presence of H2 and an electron acceptor (turnover conditions), NO acts...

Thayer S.S.; Huffaker R.C., 1983: Vacuolar localization of endo proteinases ep 1 and ep 2 in barley mesophyll cells. Plant Physiology (Rockville) 72(SUPPL 1): 118

Niimi, A.; Hopkins, S.R.; Downs, J.A.; Masutani, C., 2015: The BAH domain of BAF180 is required for PCNA ubiquitination. Monoubiquitination of proliferating cell nuclear antigen (PCNA) is a critical regulator of post replication repair (PRR). The depletion of BAF180, a unique subunit of the PBAF chromatin remodeling complex in human cells results in reduced PCNA ubi...

Bhadauria, V.; Wong, M.M.L.; Bett, K.E.; Banniza, S., 2015: Wild Help for Enhancing Genetic Resistance in Lentil Against Fungal Diseases. Lentil (Lens culinaris) is one of the cool season grain legume crops and an important source of dietary proteins and fibre. Fungal diseases are main constraints to lentil production and account for significant yield and quality losses. Lentil has...