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Do coronary artery bypass operations prolong life?


, : Do coronary artery bypass operations prolong life?. Western Journal of Medicine 136(4): 295-308

Coronary artery bypass operations improve survival in patients with symptomatic left main coronary artery stenosis, but whether or not longevity is improved in other patients has been controversial. Small clinical studies, even when randomized, have not sufficiently controlled for the heterogeneous distribution of risk factors in patient cohorts treated medically and surgically. The first randomized study large enough to overcome such problems, the Veterans Administration Cooperative Study, showed that coronary artery bypass procedures prolonged survival only in the high-risk subgroup. The surgically treated patients suffered more perioperative morbidity and mortality and had worse long-term survival than similar patients operated on in more recent years. The European Coronary Surgery Study Group recently reported that the three-year to five-year survival of symptomatic patients with triple-vessel disease and normal left ventricular function was better if patients were randomly assigned to surgical therapy. The third and by far the largest randomized study, the Coronary Artery Surgery Study (CASS), has not yet reported long-term follow-up results. Large clinical studies, both randomized and nonrandomized, that have subgrouped patients by the number of diseased coronary arteries and by the degree of left ventricular dysfunction all show that survival with single-vessel disease is excellent and not improved by operation. Medically treated patients with double- and triple-vessel disease who have good left ventricular function generally now have a five-year survival greater than 85 percent and only two of the major studies suggest that it is improved by operation. The results of most studies, however, suggest that bypass operation prolongs survival in symptomatic patients when left ventricular dysfunction coexists with double- and triple-vessel disease. Continually improving surgical techniques may potentiate the small survival differences that are now apparent, but until then, because the survival differences are so small, it is recommended that limiting anginal symptoms remain the primary indication for a coronary bypass procedure for an individual patient.

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PMID: 7046257


Other references

Walker, W.J.; Dowdy, R.H., 1980: Elemental composition of barley and ryegrass grown on acid soils amended with scrubber sludge. A glasshouse study assessed barley and fodder rye (Secale cereale) growth on 2 acid soils amended with high-lime scrubber sludge from a coal-fired, power-generating plant. The soils used were a coarse sand (pH 4.8) and a silt loam, (pH 5.7) with s...

Longuemare, M.C.; Swanson, R.A., 1993: D-aspartate efflux from astrocytes occurs during glucose but not oxygen deprivation and is prevented by threo-B-hydroxy-aspartic acid. Society for Neuroscience Abstracts 19(1-3): 1772

Wisecup, W.G.; Day, P.W.; Van Riper, D.C., 1968: Thrombocytopenic purpura of possible immune origin in a chimpanzee: a case report. Laboratory Animal Care 18(1): 85-91

Katsaros, C., 2002: Masticatory muscle function and transverse dentofacial growth. Numerous experimental and clinical studies have shown an association between masticatory muscle function and craniofacial growth. The present series of studies focuses on the influence of masticatory muscle function on some basic mechanisms in cra...

Kang, H-Gyoung.; Lee, S.Yup.; Jeon, H-Sung.; Choi, Y.Young.; Kim, S.; Lee, W.Kee.; Lee, H.Chul.; Choi, J.Eun.; Bae, E.Young.; Yoo, S.Soo.; Lee, J.; Cha, S.Ick.; Kim, C.Ho.; Lee, M.Hoon.; Kim, Y.Tae.; Kim, J.Hee.; Hong, Y-Chul.; Kim, Y.Hong.; Park, J.Yong., 2015: A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females. It has been estimated that the proportion of never-smokers among females with lung cancer is 53% worldwide and 75% in Korea. We conducted a two-stage study to identify genetic factors responsible for lung cancer susceptibility in female never-smok...

Narberhaus, F.; Kustu, S., 1994: In vitro activities of the isolated catalytic domain of NifA, a bacterial enhancer binding protein, and its inhibitor NifL. Abstracts of the General Meeting of the American Society for Microbiology 94(0): 207

Markello, R.; King, B.D., 1964: Halothane-Ether-Air Anesthesia. Thirty patients were anesthetized with halothane, ether, and air, then maintained on ether and air only. Calibrated draw-over vaporizers, self-inflatable bag, nonrebreathing valve, and mask were used. Arterial blood studies demonstrated that durin...

García-Rey, C.; Bouza, E.; Aguilar, L.; García-de-Lomas, J.; Baquero, F., 2003: Evolution of penicillin and erythromycin co-resistance in Streptococcus pneumoniae in Spain. The temporal dynamics of penicillin and erythromycin co-resistance in Streptococcus pneumoniae based on two extensive multicentre Spanish surveillance SAUCE studies (1996-1997 and 1998-1999) is presented. Erythromycin resistance among penicillin n...

Thrall, M.J., 2016: Effect of Lower Anogenital Squamous Terminology Recommendations on the Use of p16 Immunohistochemistry and the Proportion of High-Grade Diagnoses in Cervical Biopsy Specimens. The Lower Anogenital Squamous Terminology (LAST) group has recommended that cervical intraepithelial neoplasia (CIN) terminology be replaced by squamous intraepithelial lesion (SIL) terminology, with p16 immunohistochemistry used to separate lesio...

Serre, F., 1974: The tallest widest and oldest trees in the world. Some trees are gigantic; sequoias (Sequoia gigantea and S. sempervirens) are among the most famous. They can be multimillenarians, but as far as age is concerned, they are at the present time supplanted by high altitude pines belonging to the spec...