+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Drosophila as a tool for the rapid assessment of chemicals for teratogenicity

, : Drosophila as a tool for the rapid assessment of chemicals for teratogenicity. Teratogenesis, Carcinogenesis, and Mutagenesis 2(3-4): 293-301

Drosophila melanogaster is being investigated for its potential to aid in identifying priority chemicals for teratologic study. The method encompasses treating larvae over the entire metamorphosis period, i.e., from the egg through three instar stages to pupa formation, by incorporating the test chemical into the medium. Adult flies are systematically examined under a binocular microscope for external morphological anomalies. Data from treated flies can be compared with those from concurrent control flies using standard statistical tests. Results from this developmental work reveal a dramatic and reproducible response of Drosophila to various chemical treatments. Validation studies, testing known teratogens and nonteratogens, are necessary before such a system can be incorporated into existing teratologic screening regimens.


PMID: 6130628

Other references

Barthe, E., 1945: Tableaux analytiques illustres des Coleopteres de la faune franco-rhenane. Adephaga , pp. 435-466 (1935), 467-472 (1936); Polyphaga 1938 pp. 1-16 figs. Unknown

Ellis M.B.; Holliday P., 1971: Cochliobolus heterostrophus conidial state drechslera maydis. CMI (Commonwealth Mycological Institute) Descriptions of Pathogenic Fungi & Bacteria 31(301-310): NO

Miller, R.L., 1996: Pepper spray exposure during a carjacking attempt. Journal of Emergency Nursing: Jen 22(5): 390-392

Moriyama K.; Nomoto K.; Nakashima A., 1980: Studies of electro cardiographic diagnosis of right ventricular hypertrophy and of the incidence of arrhythmias and left ventricular abnormalities in patients with chronic obstructive pulmonary disease with moderate to severe pulmonary hypertension. In 28 hospitalized patients with chronic obstructive pulmonary disease (COPD) with a pulmonary artery mean pressure (PAm) > 18 mmHg, incidence of ECG pattern of right ventricular hypertrophy (RVH) and the prevalence of arrhythmias and left vent...

Popovich, AP., 1976: Certain data on studying the gonotrophical cycle of the great grey gadfly under conditions of the steppe zone of the Ukraine. Vestnik Zool, 3: 76-79

Lakshmanan A.R.; Bhatt R.C., 1982: The low temperature and high temperature response of calcium sulfate dysprosium dosimeters to x rays and gamma rays. International Journal of Applied Radiation & Isotopes 33(6): 464-466

Rădulescu, D.; Pacescu, E.; Pătraşcu, T.; Budu, S., 1991: Malignant anorectal melanoma. Apropos 1 case. A case of malignant anorectal melanoma is reported, which was treated by anorectal-sigmoid amputation, operation which did not prevent the occurrence, after 6 months, of metastases in the inguinal lymph nodes. On the basis of the reported case, th...

Jimenez, J.; Whelan, D.; Sundstedt, V.; Gutierrez, D., 2010: Real-time realistic skin translucency. Diffusion theory allows the production of realistic skin renderings. The dipole and multipole models allow for solving challenging diffusion-theory equations efficiently. By using texture-space diffusion, a Gaussian-based approximation, and progra...

Grubb, N.R.; Campanella, C.; Fox, K.A.A.; Fleming, A.; Sinclair, C.; Sutherland, G.R., 1995: Doppler tissue imaging for assessment of skeletal muscle graft function after cardiomyoplasty. European Heart Journal 16(ABSTR SUPPL ): 24

Balint, Zsolt., 1993: Catalogue of polyommatine Lycaenidae (Lepidoptera) of the xeromontane oreal biome in the Neotropics as represented in European collections. Reports of the Museum of Natural History University of Wisconsin-Stevens Point, 29: 1-45