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Early indicators of diabetic nephropathy. Changes in selective proteinuria

, : Early indicators of diabetic nephropathy. Changes in selective proteinuria. Recenti Progressi in Medicina 85(11): 540-545

Increased morbidity and mortality occur in diabetics with kidney disease. The decrease in fixed anionic charges is considered an early abnormality occurring well before any clinical sign of disease. It has been attached importance to the study of protein charge-selectivity decreased in diabetes in order to find the parameters which highlight the initial preclinical stage of diabetic nephropathy. To investigate the role of protein charge in early diabetic proteinuria, the clearance of protein differing in charge and/or size (anionic and cationic IgG, albumin) was evaluated in type 1 diabetic patients: 18% of them showed increased values of albuminuria. Anionic and total IgG clearances significantly increased in 30% and 12% of the patients and were correlated with the duration of the disease. The anionic/cationic IgG clearance ratio tended to increase in parallel with albumin clearance, but once above macroalbumonuric levels, it tended to fall again, indicating the concomitant presence of size-selectivity loss. In addition to albumin excretion, the anionic IgG clearance and the anionic/cationic IgG ratio, may be valuable in assessing early kidney protein charge-selectivity impairment and in better characterizing normoalbuminuric patients and those in the preclinical stage of diabetic nephropathy.


PMID: 7855388

Other references

Jürgens, T.P.; Reetz, R.; May, A., 2013: No relevant modulation of TRPV1-mediated trigeminal pain by intranasal carbon dioxide in healthy humans. Nasal insufflation of CO2 has been shown to exert antinociceptive respectively antihyperalgesic effects in animal pain models using topical capsaicin with activation of TRPV1-receptor positive nociceptive neurons. Clinical benefit from CO2 inhalat...

Lamikanra A.; Ako Nai A.K.; Ola O., 1989: Incidence of multiple antibiotic resistances in organisms isolated from cases of infantile diarrhea in a nigerian oral rehydration therapy clinic. A total of 247 bacterial isolates were obtained from diarrhoeal patients aged 0-60 months in an oral rehydration therapy clinic in Ibadan and tested for sensitivity to 11 antibiotics using the disc diffusion method. Fifty isolates obtained from ap...

Perez Carro, L., 1996: Avulsion of the patellar ligament with combined fracture luxation of the proximal tibial epiphysis: case report and review of the literature. Disruption of the extensor mechanism of the knee joint at the insertion site of the patellar tendon into bone is a somewhat common injury. Avulsion of the patellar ligament associated with fractures of the proximal tibial epiphysis is an extremely...

Stannard, S.R.; Constantini, N.W.; Miller, J.C., 2000: The effect of glycemic index on plasma glucose and lactate levels during incremental exercise. Consumption of low glycemic index (GI) foods before submaximal endurance exercise may be beneficial to performance. To test whether this may also be true for high intensity exercise, 10 trained cyclists began an incremental exercise test to exhaus...

Beratis, I.N.; Rabavilas, A.D.; Kyprianou, M.; Papadimitriou, G.N.; Papageorgiou, C., 2014: Investigation of the link between higher order cognitive functions and handedness. The study aimed to investigate the hypothesis that in high-functioning individuals the left-handedness phenotype facilitates the performance of executive-related tasks that engage the right hemisphere. The Trail-Making Test and Letter Number Seque...

Israel, W., 1910: Die Najaden des Weidagebietes. Frankfurt a M NachrBl D malakozool Ges Beilage No 4: 49-56

Triantaphyllidis, G.V.; Criel, G.R.J.; Abatzopoulos, T.J., 1997: International study on Artemia. LVII. Morphological and molecular characters suggest conspecificity of all bisexual European and North Artemia populations. ine Biology 129(3 ): 7-87

Henry F.T.; Kirch T.O.; Thorpe T.M., 1979: Determination of trace level arsenic iii arsenic v and total inorganic arsenic by differential pulse polarography. Speciation of As(III), As(V) and total inorganic As [As(tot)] was achieved by differential pulse polarography. As(III) was determined directly in 1 M HClO4 or 1 M HCl. As(tot) was measured in either of these supporting electrolytes after prereduct...

Albadran, H.A.; Chatzifragkou, A.; Khutoryanskiy, V.V.; Charalampopoulos, D., 2015: Stability of probiotic Lactobacillus plantarum in dry microcapsules under accelerated storage conditions. This study investigated the stability of freeze dried and fluid bed dried alginate microcapsules coated with chitosan containing model probiotic bacteria, Lactobacillus plantarum, during storage for up to 45days at different water activities (0.11...

Giannone C., 1985: The dietetic schedule in collective nutrition in the light of the technology of the manipulations utilized. Clinica Dietologica 12(1): 112-113