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Effect of adrenaline on protein and RNA biosynthesis in different organs of white rats

, : Effect of adrenaline on protein and RNA biosynthesis in different organs of white rats. Voprosy Meditsinskoi Khimii 27(4): 471-475

Synthesis of RNA and proteins/total, histone and non-histone proteins/was studied in rat liver, spleen, kidney and heart tissues within 3 and 24 hrs after adrenaline administration. The rate of synthesis of RNA10-65 degrees, total and non-histone proteins was increased in liver and kidney tissues, while the synthesis of these proteins and RNA was unaltered in spleen tissue. The rate of histone protein synthesis was unaltered in all the tissues studied. Incorporation of labelled precursors into actin, myosin and RNA was increased in heart muscle within 24 hrs after adrenaline administration. Experiments with 2-14C-glucose showed that increased oxidation of glucose via the pentose-phosphate pathway, conversion of glucose into ribose and the subsequent incorporation of ribose into the synthesized RNA were mainly responsible for the alterations of the nucleic acid synthesis observed in heart and liver tissues.


PMID: 6170165

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