geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of antibiotics in the prevention of jejunoileal bypass-induced liver dysfunction


, : Effect of antibiotics in the prevention of jejunoileal bypass-induced liver dysfunction. Digestion 23(1): 9-15

Administration of antibiotics has been reported to prevent or minimize liver dysfunction in experimental animals having been subjected to jejunoileal bypass, suggesting that jejunoileal bypass-induced liver dysfunction results from production of toxic substances by bacteria in the defunctionalized bowel. However, improved absorption will also prevent bypass-induced liver injury. We studied the effects of tetracycline on the development of bypass-induced liver dysfunction and compared it to the mucosal adaptation of the intact bowel after bypass. After 6 weeks, rats subjected to bypass but not given antibiotics had decreased levels of serum triglycerides, hepatic cytochrome P-450, and hepatic pentobarbital hydroxylase. Evaluation of intestinal mucosal hyperplasia after bypass indicated that animals given antibiotics after bypass developed greater increases in mucosal DNA content, mucosal protein, and mucosal weight than bypassed animals not receiving antibiotics. We speculate that the beneficial effects of antibiotic administration on liver function after bypass may be a result of improved absorption.

US$29.90

PMID: 7084568


Other references

Voskanyan V.E.; Arutyunyan M.G.; Unanyan A.A., 1986: Concerning the flora and vegetation of the gridzor river valley armenian ssr ussr. Biologicheskii Zhurnal Armenii 39(7): 614-616

Kolodkin V.V.; Nashivankin V.I., 1975: Use of punch cards for accumulating and analyzing data on the sanitary epidemiological state of rural populated areas. Gigiena i Sanitariya (6): 40-41

Rekshnia, An, 1980: Evaluation of feeds according to expenditures for labor. Prigotovlenie otsenka i skarmlivanie kormov Ministerstvo sel'skogo khoziaistva Latviiskoi SSR Latviiskii nauchno issledovatel'skii institut zhivotnovodstva i veterinarii otvetstvennyi redaktor K IA Kiaune: 9

Burns, E.O.; J.E.B.iggs., 1964: Economic investigation of dairying practices Wide Bay Area, interim report no. 2. Irrigated pastures. The purpose of this study is to provide economic data to assist extension officers and farmers when considering changes in farm practices. Seven case studies have been carried out, using partial budgets to evaluate estimated increases in returns a...

Counotte, G.H.M., 1983: Determination of orotate in ruminant milk by high-performance liquid chromatography. This rapid method for measuring orotate in milk consists of diluting 1 ml milk with 4 ml chilled water and adding 0.2 ml 50% (w/v) trichloroacetic acid solution. After standing for at least 4 h at 4 degrees C, the sample is centrifuged, and the fi...

Pelletier, G.; Leclerc, R.; Puviani, R., 1975: Ultrastructural localization of hypothalamic hormones. L'union Medicale du Canada 104(3): 355-362

Abushanab, E.R.ed, D.S.zuki, F.S.h, C., 1978: Sterospecific microbial oxidation of thioethers to sulfoxides. application to the synthesis of R mevalonolactone. Tetrahedron letters: 37 3415-3418

Gaskins H.R.; Hausman D.B.; Martin R.J.; Hausman G.J., 1988: Evidence for abnormal regulation of prostaglandin synthesis in obese zucker rat adipose cell cultures. FASEB Journal 2(5): ABSTRACT 6506

Hall, F.R., 1973: Coronary care in the community. Royal Society of Health Journal 93(2): 87-88

Jenne, F.H., 1973: Attendance and student proficiency change in a health science class. Journal of School Health 43(2): 125-126