+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of endurance training on liver cAMP response to prolonged submaximal exercise

, : Effect of endurance training on liver cAMP response to prolonged submaximal exercise. American Journal of Physiology 240(5): R330-R334

Endurance-trained rats utilize liver glycogen at a reduced rate during exercise compared to nontrained rats. We have compared liver cAMP responses to exercise in trained and nontrained rats in an attempt to elucidate the mechanism of this adaptation. Rats were trained on a motor-driven rodent treadmill 5 days/wk for 12 wk. On the day of the test, trained and nontrained rats were quickly anesthetized after running at 21 m/min up a 15% grade for periods up to 90 min. After 45 min of running, liver cAMP had increased from 0.60 +/- 0.01 to 0.90 +/- 0.03 pmol/mg in nontrained rats whereas no significant increase had occurred in livers of trained rats. Plasma glucagon and norepinephrine levels were significantly lower in trained rats at this point. At the end of 90 min hepatic cAMP was 1.28 +/- 0.12 in nontrained compared to 0.83 +/- 0.06 pmol/mg in trained rats. Plasma glucagon was markedly elevated in nontrained but not in trained rats at this time. The lower rate of liver glycogen utilization in trained rats is consistent with the lower cAMP levels maintained early in exercise.


PMID: 6263114

Other references

Findling, R.L.; Schulz, S.C.; Reed, M.D.; Blumer, J.L., 1999: The antipsychotics. A pediatric perspective. As can be discerned from this article, antipsychotics are commonly prescribed, and they are not used to treat only psychosis. Although some data support the use of typical antipsychotics in pediatric patients with a variety of psychiatric syndrome...

Paternoster M.; Mongelli Giovanni, 2000: Hydrogeochemistry of the Telese Springs, Southern Apennines, Italy. This study deals with a chemical survey (major ions and Li (super +) , F (super -) , Br (super -) , NO (super -) (sub 3) ) on water samples of the Telese thermal spring emerging in the Benevento area, collected from April 1998 to April 1999 with a...

X.X.ang; Xin N.X.n, 2003: Broad-spectrum cytoprotector: Amifostine. Amifostine (WR-2721) is the first confirmed cytoprotector of broad-spectrum. The article recommends amifostine including its pharmacokinetics, the mechanism of action, and clinical use in radiotherapy and chemotherapy of tumours which is different...

Habib, E.; Elhadad, Aé., 2002: Acute appendicitis due to Pasteurella multocida. Gastroenterologie Clinique et Biologique 26(8-9): 794-795

Rakhimov, K.; Kotova, L., 1984: Change of the proteolytic activity of enzymatic systems of the pancreas and small intestine during the postnatal ontogenesis of rats. Uzbekskii biologicheskii zhurnal: ) 18-20

Stoneman, D.W., 1969: Suppurating residual cyst. Oral Health 59(1): 41 Passim-41 Passim

Anonymous, 1995: Discussion of paper from Drs Gerlach and Peacock. European Psychiatry 10 Suppl 1: 32s-32s

Liu, K.J.unn; Parikh, V.S.; Tucker, P.W.; Kim, B.S., 1993: Role of the B cell antigen receptor in antigen processing and presentation. To study the role of the B cell Ag receptor (membrane-bound Ig (mIg)) in Ag processing and presentation, we have generated several Ig transfectants that express transfected TEPC-15 idiotype (T15-Id) mIgM with phosphorylcholine (PC)-binding specifi...

Dobyns, W.B.; Ozelius, L.J.; Kramer, P.L.; Brashear, A.; Farlow, M.R.; Perry, T.R.; Walsh, L.E.; Kasarskis, E.J.; Butler, I.J.; Breakefield, X.O., 1993: Rapid-onset dystonia-parkinsonism. We studied a large family with a previously undescribed, autosomal dominant dystonia-parkinsonism syndrome. We chose to call the disorder "rapid-onset dystonia-parkinsonism" (RDP) based on the unusually rapid evolution of signs and sympt...

Lee, J.W.; Hulse, J.D.; Colburn, W.A., 1995: Surrogate biochemical markers: precise measurement for strategic drug and biologics development. More efficient drug and biologics development is necessary for future success of pharmaceutical and biotechnology companies. One way to achieve this objective is to use rationally selected surrogate markers to improve the early decision-making pro...