geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of morphine, d-amphetamine, and pentobarbital on shock and light discrimination performance in rats


, : Effects of morphine, d-amphetamine, and pentobarbital on shock and light discrimination performance in rats. Psychopharmacology 70(2): 213-217

The effects of 2 and 4 mg/kg morphine sulfate, 0.5 and 1 mg/kg d-amphetamine sulfate, and 6 and 12 mg/kg pentobaribital sodium were tested in rats in two different discrete-trial two-choice discrimination tasks. The discriminative stimuli for one task were high and low intensity shocks. In the other, correct choices were signaled by the position of a brief light flash. Morphine (4 mg/kg) significantly disrupted performance of both tasks, with more reliable disturbance occurring in the shock discrimination animals. Pentobarbital (12 mg/kg), while exerting noticeable effects on gross motor behavior, had little effect on discrimination performance; d-amphetamine (1 mg/kg) was disruptive of discrimination performance in only some animals. The results indicate that much of the effect of relatively low doses of morphine on the shock discrimination performance of rats may be due not to its putative specific antinociceptive properties, but to alterations in conceptual-judgmental processes or decreases in motivation (e.g., hunger) unrelated to pain.

US$29.90

PMID: 6776582


Other references

Heine, G.; Dahten, A.; Hilt, K.; Ernst, D.; Milovanovic, M.; Hartmann, Börn.; Worm, M., 2009: Liver X receptors control IgE expression in B cells. B lymphocytes play a fundamental role in the development of IgE-dependent allergic immune reactions. Upon appropriate activation, IgE class switch recombination is initiated in B cells, followed by terminal differentiation to IgE-secreting plasmab...

Costanzo R.B.; Barry E.F., 1989: Gas chromatographic determination of organolead compounds with an alternating current plasma detector. The performance of the gas chromatography/alternating current plasma detector as a selective detector for organolead compounds is investigated. The helium make-up flow rate and the spatial position from which the lead emission is viewed, have an e...

Krishnamurthy, D.N.gam, J.; Peshin, P.; Kumar, R., 1980: Thoraco-pericardiotomy for a foreign body in a cow. Indian veterinary journal 57(10): 853-854

Kaverzneva, M.M.; Kondrat'eva, A.P., 1973: Polychemotherapy in lymphogranulomatosis. Sovetskaia Meditsina 36(8): 38-42

Jones, F.; Riazi, A.; Norris, M., 2013: Self-management after stroke: time for some more questions?. To discuss current research and issues which contribute towards the debate on the direction of self-management programmes for individuals after stroke and make recommendations for future research. This paper includes a critical discussion on self-...

Ogawa, H.; Ohtani, I.; Akaike, T., 1998: Examination for prediction of residual cholesteatoma. Residual cholesteatoma, recurrent cholesteatoma, and the open cavity problem still remain to be solved in the surgical treatment of middle ear cholesteatoma. To avoid residual cholesteatoma, complete removal of the cholesteatoma matrix is necessar...

Bauermann, S.-Girardi; Neves, P.-Cesar-Pereira-Das; Giordani, G.; Avila, I.-Roberta-De, 1998: Pollen precipitation spectrums in the region of Canoas, Sao Paulo State, Brazil (Campus of ULBRA and vicinity). This paper presents results obtained for pollen precipitation studies in the Canoas region of Rio Grande do Sul, Brazil for the period from October, 1995 to September, 1996. The experimental data obtained permitted us to determine pollen seasons f...

Mikhalev, I.D., 1965: Clinical value of protein sedimentation tests in myocardial infarction. Vrachebnoe Delo 4: 141-142

Chatel, G., 1998: Nursing care. The place of the nurse in care networks. Soins; la Revue de Reference Infirmiere: 12-13

Blumberg, A.; Weidmann, P.; Ferrari, P., 1992: Effect of prolonged bicarbonate administration on plasma potassium in terminal renal failure. In hemodialysis patients with hyperkalemia, i.v. sodium bicarbonate has recently been found to be ineffective in lowering plasma potassium within one hour. In the present study the effect of a prolonged bicarbonate infusion on plasma potassium was...