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Effects of morphine, levonantradol, and N-methyllevonantradol on shock intensity discrimination

, : Effects of morphine, levonantradol, and N-methyllevonantradol on shock intensity discrimination. Journal of Clinical Pharmacology 21(8-9 Suppl): 341s-347s

The effects of morphine, levonantradol, and N-methyllevonantradol administered to squirrel monkeys by intramuscular injection were examined on an electric shock discrimination test. Two discrete responses were used to measure discrimination of the presence or absence of a shock at two different intensities (0.45 and 0.15 mA). The percentage of responses that were correct, the response latency, and the response probability in the presence or absence of shock were determined. Morphine (0.3-1.0 mg/kg) decreased the percentage of correct responses in the presence of both shock intensities, although effects at the higher intensity were slight. Levonantradol (0.017-0.03 mg/kg) and N-methyllevonantradol (0.01-0.017 mg/kg) only decreased the percentage of correct responses at the lower shock intensity, Neither morphine, levonantradol, nor N-methyllevonantradol consistently decreased the percentage of correct responses in the absence of shock. Morphine, levonantradol, and N-methyllevonantradol also produced dose-related increases in response latency both in the presence and absence of shock; increases in response latency were greater in the absence of shock than in the presence of shock.


PMID: 7298872

Other references

Gobbett D.J., 1972: Carboniferous and Permian stratigraphic correlation in southeast Asia. Lower Carboniferous of southeast Asia closely comparable to that of Europe; middle Carboniferous, upper Carboniferous, and Permian identified with the Tethyan.

Poskus, E.; Peña, C.; Pérez, A.R.; Vita, N.; Heinrich, J.J.; Paladini, A.C., 1982: Human, bovine, and equine growth hormone antibodies in patients treated with human growth hormone. The immunological behavior of sera from hypopituitary patients treated with human GH (hGH) has been studied by homologous and heterologous RIAs using 125I-labeled hormones. Along with antibodies against hGH, antibodies exhibiting antibovine and an...

Wahlster, S.; Wijdicks, E.F.M.; Patel, P.V.; Greer, D.M.; Hemphill, J.Claude.; Carone, M.; Mateen, F.J., 2015: Brain death declaration: Practices and perceptions worldwide. To assess the practices and perceptions of brain death determination worldwide and analyze the extent and nature of variations among countries. An electronic survey was distributed globally to physicians with expertise in neurocritical care, neuro...

Kemp, D.R.; Percy, D.H.; Hayes, M.A., 1991: Lack of effects of viral sialoadenitis and depletion of epidermal growth factor on initiation of hepatic carcinogenesis in the rat. Sialodacryoadenitis (SDA) is a commonly-encountered coronaviral infection in laboratory rats that causes acute destruction of submandibular salivary glands. SDA results in depletion of salivary epidermal growth factor (EGF) and may thereby affect...

Anonymous, 2013: SCS curve number method in Narmada basin. The SCS-CN method is an event-based model developed by the USDA Soil Conservation Service (SCS). The Curve Number (CN) is a land-cover index for a given land and soil type to determine the amount of rainfall that infiltrates into the ground and th...

Koch, F., 1919: Fauna gornje krede Lagrebacke Gore. Glasnik Hrvatskoga Prirodoslovnoga Drustva Zagreb, 312: 237-239

Redikorzev, V., 1922: Pseudoscorpions nouveaux II. Annales du Musee Zoologique Petrograd, 23: 257-272

Cherry, J.M., 1991: Codon usage table for Xenopus laevis. Methods in Cell Biology 36: 675-677

Ertl, L.; Lill, W.; Matejka, M., 1988: Transdental titanium pin fixation (Dildei Pins). Zeitschrift für Stomatologie 85(6): 379-384

Camps J.; Pizarro I.; L.V.lle A.; Masana L.; Prats E.; Joven J., 1990: Plasma lipoproteins and anemia in alcoholic liver disease. Journal of Hepatology 11(SUPPL 2): S80