+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of moxibustion on the function of MDR gene product, P-glycoprotein (P-170)

, : Effects of moxibustion on the function of MDR gene product, P-glycoprotein (P-170). Zhen Ci Yan Jiu 19(2): 69-71

The experiments were performed on BABL/c mice with S-180R adriamycin resistant tumor cells. This animal model was used to analyze the drug accumulation in the S-180R cells by flow cytometer. The drug accumulation presents the pump activity of multidrug resistance (MDR) gene product P-glycoprotein (P-170) in the cell membrane, A weak inhibition was found when moxibustion at Guan-Yan point alone. And a very significant inhibition was observed in the presence of low-dosage of verapamil, but not at high dose. This study may develop a new way to research the mechanism of acupuncture and moxibustion at molecular level, and may be useful to overcome the anticancer drug resistance.


PMID: 7750182

Other references

Correia, I.; Alves, Hélder.; de Almeida, A.Tomás.; Garcia, D'Jamila., 2010: Norms regarding secondary victimization of bullying victims: do they differ according to the victim's categorization?. Two studies with a 2 valence of the image (positive, negative) x 2 victim's category (ingroup; outgroup) between-subjects design, investigated the existence of prescriptive norms regarding secondary victimization of bullying victims as well a...

Cremer, N.E.; Schmidt, N.J.; Jensen, F.; Hoffman, M.; Oshiro, L.S.; Lennette, E.H., 1975: Complement-fixing antibody in human sera reactive with viral and soluble antigens of cytomegalovirus. Antibody titers to cytomegalovirus were determined in 204 single-serum specimens and in 138 serum pairs, utilizing as antigen extracts of infected cells prepared by either freezing and thawing cells (FT antigen) or extracting them with a glycine b...

Deconto, L.S.; Monteiro-Filho, E.L.A., 2014: High initial and minimum frequencies of Sotalia guianensis whistles in the southeast and south of Brazil. Recent studies have proposed latitudinal variations for the whistles of Sotalia guianensis, since parameters of frequency increase from the southernmost distribution of the species (State of Santa Catarina, Brazil) toward the North. The last study...

Viney L.L., 1992: Can we see ourselves changing? toward a personal construct model of adult development. The purpose of this article is to create a scaffold for a constructivist model of adult psychosocial development. Personal construct psychology is introduced, followed by examination of its approach to personal change and to life-span development....

Viwattanatipa, N.; Puntien, T.; Thakkinstian, A., 2013: Systematic review and meta-analysis of maxillary change among 3 surgical techniques in cleft patients. The aim was to examine the treatment effectiveness and relapse of maxillary advancement, among 3 types of surgery in cleft patients: (1) conventional orthognathic surgery (CO), extraoral distraction osteogenesis (EDO), and intraoral distraction os...

Vinten, J.; Johnsen, A.H.; Roepstorff, P.; Harpøth, J.; Tranum-Jensen, J., 2005: Identification of a major protein on the cytosolic face of caveolae. Cav-p60, a specific and ubiquitous caveolar protein, was immunoprecipitated from solubilized rat adipocyte plasma membranes and identified as similar to a GeneBank entry annotated mouse polymerase transcript release factor (PTRF) by MALDI-TOF and...

Kraft T.; I., 1968: De sensitization and the treatment of alcohol addiction human. British Journal of Addiction 63(1-2): 19-23

Freudenberg Wilhelm, 1909: Geologische Beobachtungen im Gebiete der Sierra Nevada von Mexiko. Zeitschrift der Deutschen Geologischen Gesellschaft Pages 254-274

Rasmussen, S.; Greenberg, B.; Mindus, P.; Friehs, G.; Noren, G., 2008: Neurosurgical approaches to intractable obsessive-compulsive disorder. Although significant progress has been made over the last decade in the treatment of obsessive-compulsive disorder (OCD), approximately 20% of OCD patients remain refractory to nonsurgical therapies, including pharmacologic and cognitive-behaviora...

Lepson, J.K.imanu; Johnston, S.M., 2000: Greater Akialoa Hemignathus ellisianus Lesser Akialoa Hemignathus obscurus. Birds of North America (512): 1-24